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Research by Allen Roses, director of Duke University's Deane Drug Discovery Institute, and continuing research on the ApoEgene that has aclose link with Alzheimer's. In 1993, Dr Roses's research showed that people who have avariant of the ApoE gene have an unusually high risk of developing Alzheimer's. THese studies have been repicated by other scientists. In research presented at the international conference of Alzheimer's deisease in Vienna, Dr Roses and this team show that they have found a gene linked to ApoE called TOMM40. This gene had mutations that involved a small number of extra copies of aparticular building block of DNA in some individuals and alarge number of extra copies in others. Individuals with alarge number of extra copies- knownn as the "long repeat" version of TOMM40- coupled with ApoE3 develop ALzheimer's an average of seven years earlier- at about 70 compared to the individuals have the "short repeat" version.

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The Cajas, local savings banks, are a symbol of the excesses and lack of financial controls of the bubble years in Spain. The local savings banks were run by authoritarian leaders who remained in office for many years, and were influential in the political system. The Cajas expanded into real estate during the real estate bubble, and many of the cajas had to be merged by the federal government under new management after the bursting of the bubble. Minder describes the culture at Cajas banks in Galicia, the region in the northwest of Spain that is the home region of prime minister Mariano Rajoy. Julio Fernandez Gayoso, or known as Don Julio in the old baronial manner, was one such bank executive who ran the the larges cajas bank in Galicia as his own fiefdom till he was 80, and only quit when forced to resign in an investigation.

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Karl Rove points to major distortions in the Obama election ads on the Romney tax plan raising taxes on the middle class and increasing the deficit, issues which are shown to be important to independent or undecided voters. Romney left an opening to Democrats by not announcing more details on his tax plans, something he started to correct on the campaign trail in Ohio on Sept. 25, when he provided more details and said his plan would reduce taxes on the middle class. He said his tax cuts would not be large and would be designed around the objective of keeping the deficit under control. Earlier Democrats had seized on the vagueness of his tax plan to state that the Republicans would make a huge increase in the deficit with their tax cuts. Rove urges Romney to correct distortions in ads in the presidential debates.

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Pessimism about the pace of democratization in China with the continued dominance of the Communist party in the business and economc structures of the country. The interrelationships of the party with state owned companies and the role of its 80 million members in running all aspects of life in China. Experts in China say the 18th party Conress showed no signs of change in the party's control and no sign of experimentation to allow for change comng from within the system so that China could establish a constitutional democracy with the rule of law. Experts in China say the new leaders Jinping and Keqiang may not be able to make changes even if they wanted to, because of the party's control and the earlier presidents and prime ministers from the last two decades who still retain a strong influence on the direction of the country.

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The Obama adminstration and Democrats start the U.S. "fiscal cliff" negotiations with a call for $1.6 trillion of additional tax revenues, twice the amount of $800 billion discussed in talks with Republicans in the summer of 2011. During the Obama-Boehner talks in mid-2011, the Republicans and Democrats neared agreement for a plan to cut the deficit by $4 trillion over 10 years, with new revenues of $800 billion. Obama then pushed to raise the revenue to $1.2 trillion and talks collapsed afterwards. The Republican side through GOP senior aides says $1 trillion in new tax revenues is where this could end up. The Republicans would agree to cap deductions for the wealthy as proposed by Feldstein-Romney, and the Democrats would agree to changing Social Security and increasing the Medicare eligibility age to above 65 as proposed by Rep. Chris Van Hollen (D., Maryland) in such a scenario.

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India's Foreign Secretary Ranjan Mathai says India will only give recognition to multilateral sanctions imposed by the United Nations. He said: We have accepted sanctions which are made by the United Nations. Other sanctions do not apply to individual countries. We don't accept that position." He was referring to the sanctions program of the U.S. government, under which countries would be granted exceptions and waivers from U.S. sanctions. Iran is the second largest source for India's oil purchases after Saudi Arabia. A multi-ministerial delegation from India is visiting Iran, and the delegation says Mathai will "work out a mechanism for uninterrupted purchase of oil from Iran and to work out a financing mechanism." South Korea which gets 10% of its oil from Iran plans to get an exception to U.S. sanctions under which it would reduce Iranian imports in 6 months from the date of a U.S. sanctions law.

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Ireland's government finally accepts a three year EU bailout package for its banks and public finances of 80 billion euros or $110 billion. Germany's Finance Minister Schauble said that Ireland "will have to meet strict conditions." Ireland's 2 largest banks, Bank of Ireland and Allied Irish, will be forced to downsize, and will have to unload "nonessential assets" such as overseas operations. The IMF will provide about one-third of the loans, the European Financial Stability Facility with its 440 billon euro facility will have the largest part, and the rest of the funds will come from bilateral loans from the UK and Sweden and the EU Commission. The UK's portion is about 7 billon euros. Germany's finance minister, Schauble, told TV brodcaster ZDF, that "one can't be certain this will relieve pressure on other struggling euro members." He was referring to Portugal and Spain.

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Vice President Biden says "I would not refer to Mubarak as a dictator," showing a lack of sensitivity and understanding of the Egyptian people's demands for freedom of expression, human rights, and democracy. Harshaw says that its clear the Mubarak regime has been wounded at the core. In the light of this the Obama administration's hesitant and timid response to the protests against 30 years of one party rule under Mubarak is baffling. It means the US will have to bear the costs of being on the wrong side of public opinion in the Arab world says Harshaw. And President Obama has failed to bring the much needed change that he promised for US relations with Africa, the Arab world, and the developing world. Apart from improvement of relations with Turkey, the failure of the Obama administration to grasp opportunities for forging a new era of relations with the Muslim world.

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Sweden stands as a success story with growth of 5.5% in 2010, and Citigroup estimates expected growth of 5% in 2011. Sweden has significant export growth to the rest of Europe and emerging markets. The Swedish currency has appreciated significantly to 8.76 krona to the euro and 6.52 against the US dollar. Compared to China Sweden has not limited the appreciation in the currency, as the prime minister Fredrik Reinfeldt believes that currencies should be "market valued." The central bank raised the interest rates three times in 2010 to 1.25 %, pushing the krona up by 14% against the euro. Sweden aims to double exports to $310 billion by 2015, according to Trade Minister Ewa Bjoerling. International sales of Swedish companies drive the growth in exports. Truck maker Volvo AB's Asia sales were up 50% in the first 9 months, and Electrolux AB's sales went up by 11% in the fourth quarter.

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Foley cites a recent survey by the Zhejiang Academy of Social Sciences shown in the South China Morning Post. This survey shows 96% of respondents "resenting the rich." In 2007, the Asian Development Bank estimated the Gini coefficient for China at 0.47%, up from 0.28% in 1983, same as Sweden, Japan and Germany. Now its closer to Argentina and Mexico. This is happening as less than 70% of graduates have jobs. And a peculiar situation is occurring in China where the retail prices are not increasing but prices of real estate and of commodities like iron ore and oil are high. There is too much liquidity with $1.5 trillion of governmet manadated bank lending and inflation is rising creating a speculative bubble in stock and real estate. And there are protectionist pressures with the USA sensing that cheap imports subsidized by artificially low currency in China is worsening America's trade deficit.

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Microsoft is making management changes in the unit which makes the Xbox, Zune music player, phone software. There have been some successes with the Xbox gaming console, but the Zune music player and phone software have done poorly. Robbie Bach, the head of this group is leaving. Microsoft has also cancelled a project to make a tablet computer to compete with Apples's iPad. After years of working on the tablet computer Microsoft found itself falling completely behind when Apple's iPad became a sensational seller, and HP's acquisition of Palm also sent signals to Microsoft. Analysts say the departure of Bach who was with Microsoft for 22 years, and of other executives in the revamping, will do little to change things. They question that Ballmer has the same touch and feel for the customer, which is something rare, and which Apple has at this time.

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Only 8 months into office, the leader of the Democratic party in Japan, resigns as Prime Minister. After perceived indecisiveness by the Japanese public on the Okinawa base change issue and on issues related to cutting wasteful spending. The base issue related to a campaign promse to move the American base out of Okinawa and even out of Japan. The North Korean government's aggressive behaviour led to a changing perception of the base issue, with a lengthy disagreement with Washington and eventual reneging on the campaign promise. By this time Hatoyama's popularity dropped to 25% and he resigned. Also resigning is Mr Ozawa, the Democratic Party's secretary-general. The indecisiveness and lack of leadership on issues made it difficult to sustain the electoral support which led to the Democratic party winning an overall majority, mainly to bring change for the post Liberal Democrat era.

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Toyota's first quarter profit of $2.2 billion is a result of profits from its USA auto finance division, cost cuts and rising sales. But Toyota still faces some rough patches in the road ahead. First the rising yen at 85 yen to a dollar in the beginning of August 2010 will be one hurdle as it tries to regain export markets - Toyota has used 90 yen to a dollar in its full year forecast. Another problem is the Japanese market which is expected to slow down after incentives expire. Because Toyota has more capacity in Japan this will mean more underutilized capacity. Japanese car buying incentives expire in September. These incentives led to sales being 23% higher in the first quarter, but Toyota forecasts full year sales to fall by 9%. Another problem is regaining market share in the USA and the aging demographics of traditional Toyota buyers.

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Karl Case, co-author with Shiller, of the Case-Shiller housing index, describes what the American dream of owning a house was always all about- having a safe long-term investment with the happiness gained from ownership of one's own home. It was never really meant to become a way to pay bills, and enjoy an artificially high standard of living based on artificially high speculative returns of 30% a year. Based on the authentic verson of this dream, it is still alive, says Case. Buying a house today costs less because of lower interest rates, the costs of a house are lower, and it provides a return in the form of rent that the owner doesn't have to pay for the home. Case has not factored in unemployment and job uncertainty, especially with the worsening economic outlook in 2011. This may still depress housing markets.

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To get the agreement of the 27 countries engaged in the talks to set new banking rules, the new Basel III banking rules are being phased in over a protracted period. Some changes go into effect in 2013, but others will be put into effect by 2019. The focus on the new rules is how much capital, or "common equity" banks will be required to hold as a cushion to absorb losses in a crisis like that of 2008. Large banks will be required to hold 7% of their assets in common equity. By 2015, banks will have to begin building a 2.5% buffer of capital, which must be in place fully by 2019. No action was taken on issues such as requirements for banks to have access to ample liquidity, what systemically important banks should hold in capital, and establishing a counter cyclical capital buffer.

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New York city Mayor Bloomberg, says President Obama and Republicans should stop promising a free lunch, or something for nothing. He points to Obama's reelection strategy of higher taxes for the rich- by taxing those earning over $1 million at minimum of 30% in federal income taxes- as generating $1.1 billion, according to Congress's Joint Committee on Taxation. This would make little difference on a federal government with $1.2 trillion gap in spending and revenue. And he says Republicans who say making the Bush tax cuts permanent while at the same time cutting the deficit are promising a free lunch, with no connection to reality. The answer says Bloomberg should be to eliminate the Bush tax cuts for all groups, for shared sacrifice, and for Congress to pass the Simpson-Bowles deficit reduction plan with $4 trillion in savings on an up or down vote.

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At the current rate of reducing the 10% current account deficit by the central bank, it will be the end of 2013 when it could be brought down to 6%. This may not be fast enough as Turkey could face an external shock if sentiment of foreign investors changes before that. As Turkey partly depends on foreign investors for short term funding of the deficit, this is critical for Turkey's economy. Only one quarter of capital inflows are in the form of long term direct investment. As the situation in the eurozone worsens in 2012-2013, Turkey is in serious danger of a sharp downturn in the economy after years of growth. The IMF has cited Turkey in the list of countries where the credit growth to GDP has increased to the level of a warning light indicator. Other countries cited by the IMF are China, Vietnam, S. Africa and Brazil.

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Abbott is looking for new ways to market in emerging markets. New flavors for Ensure in Asia would include lemon-honey. And cumin-jeera jal is a flavor for a supplement for diabetics in India. Abbott has a five year contract with India's drug maker Biocon to develop products for the Indian market. Abbott faces strong competition from other nutrition companies such as Nestle in India, which has 75% of the market for baby formula in India, and now owns Pfizer's baby nutrition business. With the $10 billion already spent on the Solvay and Piramal acqusiitions in India, Abbott has less room to make further acqusiitions. It will focus on organic growth with investment of about 7% of sales in R&D to develop new products. The split in Abbott's business with the separation of the pharmaceutical unit, will lead to a more consumer product oriented company.

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A big problem Spain is facing is that the room for spending cuts is shrinking and new taxes are not generating higher tax revenues for the government. Tax receipts declined by 1.5% in the Jan-May 2012 period even with the higher taxes on income, electricity and tobacco. The revenues from VAT, value added tax, declined by 10%. Spending to aid regional governments increased by 12% and interest payments increased by 32%. Under the government of prime minister Zapatero tax income declined by 19% in 2007-2011, even after adding higher taxes on the wealthy, increasing the VAT tax and scrapping of a tax rebate. The government predicts domestic demand will decline by 3.1% in 2012. Ms Cospedal who is cutting spending in the Castilla region near Madrid, a deputy leader of the ruling Partido Popular, says in some regions the margin for additional savings is "becoming small."

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Australia's treasurer Wayne Swan blocked the proposed takeover of Australia's main stock market operator ASX Ltd by Singapore Exchange Ltd. He said that "this deal is not in the Australian national interest." He said there was a risk of Australia losing control of its clearing and settlement systems with such a takeover. He described the merits of the takeover as offering access to Asian capital flows as "overstated." Australia's exchange is the 11th largest exchange by market value and Singapore's exchange is shown at 21. In plain language he said the deal wasn't a merger, "its a takeover that would see Australia's financial sector become a subsidiary to a competitor in Asia." Investment in Australia is reviewed by the Treasury Department's FIRB, with the final decision made by the Treasurer. In this case the response was swift as FIRB pointed to major obstacles for the deal.

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The European automobile market staged a recovery in 2014 with sales up 5.7% to 12.6 million, according to the European Automobile Manufacturers Association. The big gains were made by the lower cost brands such as Renault's Dacia made in Romania, and VW's Skoda made in the Czech Republic. Dacia sales increased in 2014 by 24% to 359,141 and Skoda's sales increased by 14% to 554,479. A Dacia Sandero without air conditioning, power locks or radio is priced at 7,990 euros in France compared to a better equiped Skoda Fabia at 12,640 euros and a VW Golf at 17,388, a big price difference for budget car buyers. The major brands continue to dominate with the Golf model continuing as the best selling model in Europe. GM and Ford with the Opel Corsa and Ford Fiesta also increased market share. VW's market share is 12.7%, Skoda's 4.4%.

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U.S. Federal Reserve chairwoman, Janet Yellen, says the Fed's promise to be "patient" before raising interest rates means it will hold off for 2 months to check economic conditions before taking action. This would put the decision off till June 2015. The Fed will look at a range of factors including inflation, says Yellen. Yellen's comments to the Senate Banking Committee on Feb. 24, 2015 were- "I don't want to set down any single criterion that's necessary for rate increases to occur. We will be considering a range of evidence that pertains to the inflation outlook." In testimony Yellen said she wanted to be "reasonably confident" that inflation will return to 2% before raising rates. The Fed's measure of inflation, Commerce Department's personal consumption expenditures price index is below the 2% inflation target of the Fed for 52 of the past 68 months, and for 34 consecutive months.

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This editorial in the Economist says Scots should get fiscal autonomy, and manage their own affairs including setting minimum wage, and tax rates. It says England should not subsidize Scotland as it currently does, and this will lead to Scotland bearing additional cost of about 8 billion pounds. It reminds readers that only about 50% of Scottish voters voted for the Scottish National party in the 2015 general election, and once Scotland has to balance its own books voters would have a chance to rethink the level to which they want a welfare state. As in Quebec the nationalist party may not have the same voter support when it has to tackle the difficult tasks involved in self government. This also means Scots would not be voting on how to manage affairs in England, leading to a federation for England, Scotland, Wales and Northern Ireland.

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The first year of the Modi administration in India brings a sense of moderation to high expectations following the election, considering the many problems that need to be tackled. It also brings some help in the form of lower oil prices coming at a critical time for the Indian economy, which is overly dependent on oil imports. This enabled the government to cut fuel subsidies and control its budget deficit. By April 2015 inflation declined to 4.87%. Foreign direct investment increased by 25% to $28.8 billion in 2014-2015 fiscal year. Major steps include deregulating prices of diesel, petroleum and cooking gas, increasing foreign ownership limits for defense and insurance sectors to 47%, and opening 125 million new bank accounts for poor households. Coalfield leases and telecom spectrum allocations which suffered from lack of transparency and sold at low prices under the previous administration were reallocated in a transparent process.

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The U.S. birthrate edged up slightly for the first time since the recession of 2008 led American families of childbearing age to defer having children. There were 62.9 births for every 1000 women of childbearing age in 2014, increasing from 62.5 in 2013, according to the Centers for Disease Control and Prevention. The total fertility rate also increased slightly to 1.862 children in 2014 from 1.858 in 2013. This is below the rate of 2.1 children a woman would have over her lifetime to keep population at the same level, without immigration. Kenneth Johnson, a demographer at the University of New Hampshire, estimates about 2.3 million more births if the 2008 recession had not led women to defer having babies. In 2014 U.S. births increased 1.4% to 3.99 million children from 3.93 million in 2013. Women over 30 and better educated are showing a larger increase in births.