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A conversation with Ratan Tata at Tata's Colaba offices just as Tata prepares for the acquisition of Land Rover and Jaguar.

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Global sales growth will be from developing countries as US sales slow down to the rate of a 4-5% growth, losing 1 percentage point and be at the level growth is in Europe. This growth will mean U.S. sales of 305 billion dollars in 2009 for pharmaceuticals. Next year two thirds of prescriptions will be generics, increasing from 50% in 2003. Forecasts from IMS. Also FDA is taking a tougher line in regulation. Top seven emerging markets will grow at 12 to 13% a year in contrast- from improving economies and greater demands for spending on health care.

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The failure of mega deals like the purchase of Warner Lambert and Pharmacia by Pfizer for $178 billion to do much in the long run. Pfizer's share price has fallen 70% in a decade and its market capitalization is $95 billion. J&J and Abbott have made smaller acquisitions and J&J's acquisitions have generated stable revenues with branded health-care products.

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About $710 million of the $3 billion fine Glaxo is paying the U.S. government and states is for the Justice Department's claims about the improper marketing of the asthma combination inhaler Advair.

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A crisis situation exists in state revenue and spending needs. According to a Census Bureau report overall state revenue in the US dropped 30.8%, to $1.1 trillion, between fiscal 2008 and 2009. The gap between the spending needed to provide services in the recession and revenues is very large. States fiscal problems along with housing losses, will be the two forces acting as a drag to the US recovery in 2011-2012. State payrolls will be cut back and contracts to private companies reduced to cut spending. Declining federal help in 2011-2012, with the new focus on reducing the federal deficit, will worsen the situation. According to the Center for Budget and Policy Priorities, even with large federal help 46 states had to raise taxes and make cuts to close a combined gap of $130 billion in their current budgets. And next year 40 states already have projected gaps totaling $113 billion. Even as revenues drop, the Census Bureau report says the state government expenditures went up by 3% to provide essential services, safety net programs and education. Illinois has a budget deficit of 45 percent of its overall budget, according to the Pew Center on the States. In California it is equal to 13% of te state's total budget, and in Arizona it is 15%. For 2009 tax collections fell by 8.5%, and were partially offset by a 12.9% increase in federal help, which was a total of $477.7 billion, according to te Census Bureau report....

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The difficulties in making profits from generic drugs because of intensifiying competition among the generic drug makers.

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This article details the manner in which pharmaceutical companies like Sanofi, Novartis and other western pharma companies are using EU patent laws to have customs offices in the Netherlands and other European transit points to detain pharma shipments by Indian companies to developing countries. Cipla and Ind-Swift shipments are mentioned. India's pharma exports of generics and other medicines is $4.9 billion in 2009 according to Global Trade Information Services. Indian pharma companies are having to divert these shipments through Singapore and other transit poits to avoid this detaining of shipments and this costs more. India plans to file a complaint with the World Trade Organization according to India's commerce secretary, which one expert says it has agood chance of winning.

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The FDA sets a pathway for developing "biosimilar" drugs in the U.S. Biosimilar drugs are cheaper versions of higher cost biotech drugs. Europe has moved further ahead in this area.

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Glaxo's ad campaign behind Alli its over the counter weight control drug. Details about a novel internet program designed by Glaxo for Alli and now in use by many customers.

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The reasons Exubera was conceived by Pfizer, the events leading to the persistance with backing Exubera with large investments in manufacturing and marketing and buying out Sanofi's stake in the face of repeated setbacks, the difficulties posed by a insulin inhaler from the very beginning. Bulkiness the size of a flashlight this inhaler was embarrassing to use in public, it required regular lung exams because the FDA placed a warning on theproduct because only 10% of the product went where it was intended and 90% was inhaled into the lungs and who knows what that could do especially for asthmatics but also for others. It cost twice as much instead of $2 or 3 it cost $5 per day. And the 3 milligram packet had to be loaded into the inhaler which required instructions on how to use, one doctor saying it woul take an hour to educate a patient compared to 5 minutes for an insulin pen. Abbott and Lilly have insulin inhalers that they are bringing to market in 2009. Abbott's uses aerosol insulin instead of powder, Lilly's is the size of a cellphone. Will they work for customers? Pfizer attributed as key cause of the failure to the need for regular lung exams because of the regulator's warnings for insulin inhaled into the lungs. Are Lilly and Abbott taking this problem seriously?...

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Genentech's Levinson at a turning point looks at autoimmune diseases to find new drugs and cures.

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Avandia may lose additional sales to Actos a competing drug from Takeda Pharmaceutical if the warning label further discourages users of the drug because of heart risks. There is considerable debate within the FDA itself.

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Country Garden is turning into a worse problem than Evergrande. Both housing developer companies are in serious financial problems in China affecting the larger economy. Consider that Country Garden has $286 billion in liabilities and $7 billion in first half losses for 2023. Two years earlier Evergrande went into insolvency over extravagant projects and spending. Country Garden's problems come from a shift away from housing in the country a retreat by investors and buyers. Yet 25% of the economy and the savings of ordinary Chinese are tied up in housing. Local government finances are also strained adding to the debt burden. In the boom years housing created hyper growth, now it is in reverse acting as a drag on the economy.