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AstraZeneca PLC showed a net profit decline of 8.3% in fourth quarter 2011, on sales that remained stable at $8.66 billion compared to $8.62 billion in the prior year quarter. AstraZeneca is facing competition from low cost generics and cuts in government health care spending similiar to the rest of the industry. The company has announced new job cuts of 7,300 job for 2012, which brings total job cuts to 30,000 for the last 5 years. Most of the job cuts are in the U.S. and Europe. Hiring has continued in emerging markets leaving the net job cuts over the last 5 years at 9,600. Of the 7,300 job cuts planned for 2012, 2,200 will be in R&D departments, 1,350 in manufacturing and 3,750 in sales. AstraZeneca is changing the way it will do research and development with these changes. It will close the neuroscience research laboratories in Sodertalje, Sweden and in Montreal. It will have in its place "virtual" neuroscience units, small groups of 40-50 researchers working with academic groups and scientists outside to utilize the best science in the field. This is one of the most radical changes in R&D practices among pharmaceutical companies. In marketing the approach has shifted from having full time sales people call doctors offices to using online marketing tools and telemarketers. This approach is also being adopted for emerging markets....

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Jaiswal who made 209 in the Second Cricket Test hits a fast century in the Third Test against England to put India in a strong position on Feb 17, 2024. Jaiswal hit 3 sixes and 2 fours in 8 balls at one time in the 150 run partnership with Shubman Gill.

 

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Investment plans don't always work out. Softbank has only $30 billion on hand and it is not clear where Masayoshi Son of Softbank Japan will get the rest of the $100 billion he says he will invest in the US, says this WSJ report. There is also a question if it will go into needed infrastructure and other investments that bring the most benefit to people in the US.

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By putting the credibility of 6 Republican National Chairmen in recent years on the line, including Republican figures such as Bill Brock and Bob Dole, this op-ed article in the WSJ aims to put to rest any doubts about the rule that an absolute majority of delegates is always needed to become the nominee of the Republican Party. This is true since Lincoln won the nomination on the third ballot, and who would never have been president if this was not the rule. The party coalesced behind Lincoln after the nominee on the first ballot failed to win. This also happened when Reagan won a million more votes than Gerald Ford but gracefully conceded to Ford who had the delegate lead. Eisenhower also was nominated on the second ballot after the leading candidate failed to win the first ballot. Reasons given by the party chairmen for this setup are that the party works to elect the best candidate to represent it by coming together at the convention behind the best leader for the party in the general election. Only about 17% of eligible voters voted in the Republican primaries, with a highly fragmented vote, which make the primaries only one way of bringing in public representation, the other being grassroots leaders in each state party having their views represented as delegates, leaders of the party in prevous elections also offering their views and being represented in some form. Even the general election system of electoral votes is based on winning by state electoral votes and does not simply tally up the votes in the entire country, the framework for the Senate with 2 senators for each state, 2 for California and 2 for Wyoming is not entirely on number of voters because it was the intent of the founders for the Senate to bring representation in a different way than for the House of Representatives, all the time looking for appropriate checks and balances for good government as the goal they set above everything else....

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Friedman on the $43 billion infrastructure he saw in China and the crumbling infrastructure in New York City and driving from dilapidated La Guardia airport in New York city into the city vs the new Shanghai airport and the magnetic levitation trains into Shanghai. He says don't forget that they are mere snapshots. And he is very aware that you go 100 milews outside Beijing and you find a poor developing country. So which is the real China, no easy answers. Give credit to their dedication and all the hard work and the motivation and planning to Chinabut still ask the questions about what we should do here in America and what countries like India have to ask what they should do and go about doing it. China will have its own questions and problems to think about too as it has to figure out what their best allocation of capital will be, what their policies should be from the birth rate and demographic changes, to the environment, and to ways to bring the rest of the country and farmers into the picture and see that the gains from now on reflect the imbalances in growth. The country building the latest infrastructure will always have the latest infrastructure and that will be the next country around the corner with the capital and energy to do it, the USA or India or Russia or some other country. The real progress is in the quality of life, of health and the resources for living productive healthy lives for most of the inhabitants of any country or region and that goes beyond politics or nationalism or rivalries or vested interests of groups of people, as it depends on learning from the best that every productive mind anywhere in the world or any productive place anywhere in the world has to offer. And the thing about this is its never a goal only because in a true sense the road well travelled is the destination for this kind of progress. ...

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The port of Los Angles has a more than 25% decline in the number of containers that are moving through the port. The Port of New York and New Jersey has now overtaken Los Angeles as the main port of entry for shipping containers to the US. Ports that are gaining include Savannah in Georgia, Houston, and Charleston in South Carolina. Bottlenecks, supply chain disruptions and fears of a dockworkers strike in the west is leading to changes in how goods imports enter the US. 

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New laws in California are designed to protect renters and workers in the internet ride getting business. Landlords will not be allowed more than a 5% increase in rent annually. Workers cannot be classified as independent contractors in the ride hailing business dominated by Uber and Lyft so that workers can benefit from overtime pay, minimum wages, and sick leave.  Other laws in 2019 protect consumers privacy by requiring companies to delete information they collect and stop selling it if consumers request this. 

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A study done to observe readings for nitrogen dioxide NO2 and particulates in kitchens with gas stoves. Forty million Americans use gas stoves. For these homes the best way to reduce harmful effects is to ventilate with fresh air by opening a window or door a little bit. Particulates come from the food itself that is being cooked and this happens for both gas and induction electric stoves. Only half of American gas stove kitchens turn on the vented hood that takes the air outside, these need to be turned on.

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Sweden and Finland say they want to preserve their right of self-determination to join NATO. Russia will meet with NATO in the context of the NATO-Russia Council on Jan. 12, 2022, for discussions. Russia has given its list of grievances and demands to the US in meetings between Biden and Putin. The Western alliance and NATO aligned nations in Eastern and Northern Europe see standing firm together as the best way to counteract Russian pressures as it places 100,000 Russian troops on Ukraine's borders.

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The story of GM's self driving car Cruise stemming from its acquisition of a startup in California in 2016. It started with GM perceiving a threat from driverless cars and ride hailing firms. After the acquisition GM's share price rallied. Investments came in from Softbank and other companies. The company planned a robo-taxi service to test its cars in American cities. This story covers the accidents as GM pushed for it too early till California pulled out of the program.

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NYT provides an extraordinary display of working age population demographic data in graphics for the world and individual countries to 2050. India, Indonesia, Bangladesh, Pakistan, Egypt and African countries are given the opportunity to make progress similar to South Korea, Japan and China over the next 25 years. India with 1.4 billion people and a determined federal government can set the stage for the type of progress that can modernize the country and build a level of infrastructure that compares with the best in Europe, the US and Japan.

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The historic letter of president Joe Biden to Congress and to the American People shows what this struggle is about to defend and secure the rights of the working people and families of America in ways that Lincoln, Wilson, TR, FDR and Truman did in their day. To defend the American people from the intrigues and misinformation about where America's future lies, to defend the best hope of this and future generations, to defend the rights, freedoms and hope of free people everywhere.

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The coronavirus pandemic death toll reaches 700,000 making it the deadliest in history. In 2021 the death toll increased with another wave now in the southern and western states such as Florida, Texas in the south, and California, Idaho in the west, with deaths concentrated among the unvaccinated.

The vaccination drive stalled by August 2021 leaving a large number of people between 18-35 unvaccinated mostly in the south and some in western states. States with large Republican support tended to show higher vaccination resistance though the reasons for not getting vaccinated were complex and some misinformation played apart in fear of vaccines. Vaccine supplies were ample in the US.

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Automakers in the U.S. may be getting more than they expected from the Trump administration's effort to  loosen pollution control laws for automobiles. The Trump administration's effort to change automobile fuel efficiency and pollution laws will run into challenges from the state of California which is allowed to set its own rules under the Clean Air Act.

This would create two different markets inside the U.S. one following California type stricter rules for fuel efficiency and mileage, and for pollution, and a different market with looser laws for the rest of the country. This is something the automakers face as unintended consequences of their actions to loosen the fuel efficiency legislation.

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Stay at home lockdowns, closure of schools in South Africa and other African countries is harder because of lack of widespread internet, says this report in DW.com from South Africa. South Africa declared a 21 day lockdown on March 27. South Africa does better than the rest of Africa with 53% of the people able to use the internet. The internet access in other African countries is only for about one third of the people. This is actually lower than that in practice. Only 12% of Kenyans have internet in their homes, mostly in Nairobi and large cities, and 70% with internet access have this through their phones.

This provides opportunity to ensure wider use of radio as most homes have radio. There are new ways for teachers to interact with students. Teachers in Kenya hold a lesson on radio and students send in their questions on WhatsApp.

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With about one fourth the population of California Michigan has done approximately 100,000 tests, compared to about 213,000 in California. This is about twice the rate of testing in Michigan- with the help of the U.S. government- compared to testing taking place so far in California. The lack of aggressive testing in California could also mean there is a lot that remains unknown about the extent of the spread of coronavirus in California. 

That Governor Newson ordered New York to shelter in place on March 19, 3 days after the stricter stay at home order in France on March 16 requiring a document to show police to go outside, shows California like the rest of the country was not that much different. Beaches were packed in California on the weekend of March 15. A lot remains unknown at this point about the spread of the virus. The urban sprawl areas in Michigan are as hard hit as Detroit.

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Britain has opted to take the approach of South Korea and Taiwan, where the app developed for contact tracing adopts a centralized approach sending information to a central server.  The Google Apple app is taking a decentralized approach where the information on who has the virus and who they came into contact with is not sent to a central server. Asian countries with success in lifting lockdowns have adopted a centralized approach as this has given proven results in allowing the rest of society to function smoothly without lockdown, by isolating a few people who have or have come into contact with people with virus. In a crisis of this magnitude with the huge risks involved democracies such as South Korea and Taiwan, other Asian countries, and now Britain, see less risk in relying on the centralized approach, because it works more effectively to accomplish the task of limiting spread and letting society function without lockdown.

 

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The Oxford vaccine manufactured and distributed by Astra Zeneca faced manufacturing problems in 2020. The company is fixing these manufacturing problems and plans to meet demand from Britain, the European Union, and the rest of the world. It plans to double vaccine monthly production to 200 million doses monthly by April. CEO Pascal Soriot says "Is it perfect? No, it's not perfect, but it's great, and tell me who else is making 100 million doses in February?" The Oxford vaccine has shown strong protection against severe coronavirus symptoms and is important in the fight against the pandemic. To tackle variants of the coronavirus the company plans to have another jab developed by autumn this year.

Britain and India are depending on Oxford vaccine to vaccinate large parts of the population. India has a second vaccine developed by Indian scientists at Bharat Biotech that is also in use.

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This expert who reviews the Internet for the NYT says that he is comfortable with many of the tools that existed back in 2009, Recent tech advances have costs in privacy, excessive advertising, lack of calm moments to reflect, constant buzz that disturbs more than it helps quiet thinking, and losses in productivity for small gains in bits and pieces here and there. Not much in the App world that he finds extraordinarily useful considering all the costs that are not tallied up because they affect our lives taking away a lot without one noticing.

It takes a lot of wisdom and individualism to take only what helps one and put away the rest of what is sent our way by so called Tech. Not foregetting that before the word Tech was coined the world had already invented the computer, jet planes, and the silicon chip, and put men on the moon. Hype. Surely.

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Krugman sees Germany's Chancellor Angela Merkel and her Finance Minister Peer Steinbruck stalling an overall stimulus plan for the whole of the EU. Merkel told a political party meeting that Germany "wasn't going to participate in this senseless race for billions." And Steinbruck said Britian was engaging in "crass Keynesianism". True Germany has not been on the debt financed consumption binge that the UK has been in and does not have a housing bubble bursting like the UK, but says Krugman Germany is also facing a crisis like the rest of Europe. Ifo, German Research Insttitute points to the worsening crisis in Germany as the worst since the 1940's. Part of the reason is that Germany is abig exporter and its medium sized companies are big exporters and a large part of the economy. With the slowdown in China and the rest of Asia these exports have been hit hard. See the links to this. What happens without acoordinated response in the EU? Krugman warns that it would lead to leakages in which the advantages of the stimulus by the rest of the EU would not be as effective as with a coordinated response including Germany the biggest EU nation. He expects Merkel to wake up to the need for this once she sees the new numbers. ...

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Anne Applebaum describes comments of European diplomats she talked to who were strongly critical of British prime minister Cameron's efforts to win special protections for London's financial district, the City. They described this as petty, especially when the European negotiators were working to save the Euro currency. Sarkozy said recently that the British hate the euro, and have done little to help, and should shut up. And that is the sense today in European capitals even as Conservatives in Britain applaud Cameron's move. The result is to isolate Britain from the rest of Europe, even as Britain will be put in a position to having to play by rules set by the other 26 countries in the European Union, who are its main trading partner.

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Three finance ministers, Mr. Sinha, Mr. Chidambaram and Ms. Sitharaman, have favored strong action on PMLA, the preventing money laundering law, saying that it is of serious importance for the integrity and sovereignty of the country, says the Indian Supreme Court as it reproduces these statements. All have argued at different periods in favor of the interpretation of the law consistent with the judgement given by a special bench of the Indian Supreme Court last week.  It has significance in another respect, which is in restoring the faith of hundreds of millions of ordinary citizens in the local, state and federal governments. A faith that has been seriously eroded since independence and which affects the development of infrastructure and modernization of India, and the building of the defense capabilities of the country that rest on making India an advanced economy similar to China. India cannot build up its own financial and human resources to tackle that task with the constant erosion of trust in the management of development and infrastructure and in delivery, that has and is taking place in the country today. ...

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Claire Moses reports for the NYT from Woudenberg, Netherlands, her home country. The 1.6 million cows on Dutch dairy farms are a leading producer of nitrogen emissions in the country. EU and Netherlands laws limiting these emissions would require a much smaller population of cows. To meet the cuts in emissions Dutch dairy farmers will have to significantly reduce their farming operations and number of cows in each farm. Netherlands is a major dairy farming nation with 8.2 billion euros of dairy exports including Edam and Gouda cheeses and 13.8 billion kilos of milk.  Dutch farmers have launched nitrogen protests for 2 years saying their livelihood is threatened. In a nation of 17 million people about 40% supports the farmers, but this support is declining with increasing impact of droughts and fires, impact on agriculture and transportation on rivers, takes its toll on Europe and the rest of the world. Netherlands has set aside $25 billion to aid farmers making the transition to a smaller nitrogen footprint. It also requires the Dutch to shift their diet to fewer animal proteins, to grain and other non animal proteins. ...

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Prime minister Theresa May of Britain announces her plan to spend an additional 20 billion pounds a year on the National Health Service. Over five years the commitment is for an additional 70 billion pounds. By 2023 this will bring the UK to the point where it is spending the same proportion on health care as France. This also fulfills a promise made by the pro Brexit campaign. May says some of this would come from higher taxes, and 9 billion pounds that the UK contributes to the European Union each year would go to pay for the additional funds to the NHS. The 2017 British election with Labor winning 40% of the vote has affirmed the shift in public sentiment to greater commitment of funds for health and education. Poorer communities in Britain that were left behind tended to vote for Brexit, with a large gap widening between London and the rest of the country. Higher commitment to NHS is part of the shift in perception that the needs of health, education and underserved communities are the new priorities. ...

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Temperatures not seen or ever recorded by weather monitoring systems of 126 degrees Fahrenheit in New Delhi, India's capital May 30, 2024. This is 52.3 degrees Centigrade, with dangerous sweltering heat across all of northern India. Delhi's Lt. Governor called for paid leave for Delhi construction workers for 1-3 pm. Election rallies in India's general election drawing huge crowds even in such sweltering heat shows the impatience of the population of over 1 billion people with corruption and poor governance in some states and the efforts by prime minister Modi to ensure good governance and large investments for modernization of the Indian economy in infrastructure and transportation, logistics and manufacturing. It may be astounding to realize that voting still reached 68-71% of eligible voters in such weather conditions. India is the fastest growing economy in the world and now a beacon of progress in the middle of stalled efforts throughout Africa, Asia and Latin America following the pandemic, yet it too faces challenges from climate change just as severe as in the rest of the world with heat waves, floods and wildfires. ...