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When regulators told J&J that tens of millions of doses at a Baltimore plant had to be discarded for contamination, the initial enthusiasm for a one dose vaccine began to fade. Production problems and the pause in the vaccine J&J as problems are sorted out, is making the J&J vaccine less effective in this crisis. Only 11.4 million doses have been adminstered of J&J vaccine says the NYT, making its role less significant.

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Hungary's president Orban visits Ukraine and mets Zelensky for peace talks. Hungary's has assumed the presidency of the EU in 2024. He suggests a ceasefire from Ukraine first to bring a settlement to the war.

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Simon Tisdall of the Observer in London, England, had this to say about Kamala Harris and her taking up the 2024 campaign after the withdrawal by president Biden. He call it a frsh choice in terms of personality, energy, policy, tone, trustworthiness and moral integrity. A generational leap says Tisdall, and the possibilities of a new morning, a new dawn in 2025.

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Governor Walker of Wisconsin defends steps he is taking to cut the budget deficit.

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The $17 discount for Russian oil to Brent crude is a result of the president's efforts with sanctions plus tariffs on China and India to cut oil purchases from Russia. This puts a strain on Russia in financing the war with Ukraine. Bothe China and India have cut purchases of Russian oil in recent weeks and the Indian refinery at Jamnagar no longer gets Russian oil, according to recent reports. DJT was criticized for his stance on Indian tariffs as inconsistent with the agreement with China on rare earths. It now appears that China and India have both agreed to stop financing the Russian war effort with big oil purchases and are shifting it to other places such as Brazil, Guyana and Canada. India plans large oil purchases and arms purchases from the US and this is part of the trade agreement being negotiated with India. About one third of the additional 240 million barrels of oil on the seas in tankers is Russian oil being stored for lack of buyers with total oil on waters at 1.4 billion barrels. This has led to a 48% increase in tanker costs to $125,000 a day. All this makes it harder for the Russian economy to sustain the war effort as the US pushes both sides to settle the Ukraine conflict in the 28 Points Peace Plan negotiated with important Russian negotiators in Washington DC over 3 days last week. ...

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Russian withdrawal from the grain deal in July 2023 makes the Black Sea an increasingly dangerous place. Russia fills the skies with its aircraft and the US and allies fly planes over international waters. Ukraine drones carry explosives towards Russian ports and ships.

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Problems President Buhari of Nigeria faces problems with the Avenger group in the Niger Delta and disruptions by the group in the flow of oil. As a result Nigeria now lags behind Angola in oil exports. The decline is about 25% in oil production compared to a year earlier.  Years of neglect and frustration in the south are fueling the movement- the Niger Delta people feel oil resources do not benefit their region and benefits going to politicians and people in the government. Buhari has not visited the Niger Delta and a recent trip was postponed leading to a a sense of alienation. The south is Christian and feels discriminated against by Buhari, a Muslim from the north.  Separatist sentiment is growing in Biafra. And the Boko Haram movement has led to 2 million refugees in the north of the country. The result is that Nigeria faces a crisis.

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This report in the Washington Post points out that more than half, about 12,000 homes, needing lead free pipes in Flint, Michigan, are still waiting. This 4 years after lead contamination in Flint water was shown to be over 800 times more than the approved levels. In parts per billion 13,000 compared to 15 ppb upper allowable level. 

About 12,000 children in Flint from the poorest families were exposed to lead contaminated water when this was discovered in 2014. 

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Olaf Scholz of Germany has to balance the need for continuing trade with China with the effort to diversify its supply chain and increase manufacturing in Germany as he visits China. Germany is entering a new phase in its trade relations in Asia, one very different from the Merkel era.

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The US with 5% of the world's population has 25% of the world's prisoners. The US has 2.3 million peope behind bars according to the International Center for Prison Studies. China with 4 times the population has 1.6 million people in prison. The US has 751 people in prison per every 100,0000. It varies a lot within the states Louisiana at 1138 per 100,000 and Maine at 273 being the lowest, Minnesota at 300 is more like Sweden at 80 per 100,000 people.Interestingly it shot up in 1975, for a long period from 1925 to 1975 it was about 110 per 100,000. Explanations are given such as the war on drugs but only 500,000 are in prison for drug offences, so its only part of the explanation. tougher sentencing, availability of handguns and higher murder rates, and even the election of judges who respond to public opinion favoring tougher sentencing, are all given as answers. Interestingly Canada's crime rates parallel those seen in the US but the imprisonment rate has been stable for the last 40 years according to one expert Mr. Tonry. He says that english speaking countries have higher prison rates than French and other European peoples. Higher prison rates for black people are known to be the case in English speaking countries but no figures are given here. This is part of the problem....

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Research by Allen Roses, director of Duke University's Deane Drug Discovery Institute, and continuing research on the ApoEgene that has aclose link with Alzheimer's. In 1993, Dr Roses's research showed that people who have avariant of the ApoE gene have an unusually high risk of developing Alzheimer's. THese studies have been repicated by other scientists. In research presented at the international conference of Alzheimer's deisease in Vienna, Dr Roses and this team show that they have found a gene linked to ApoE called TOMM40. This gene had mutations that involved a small number of extra copies of aparticular building block of DNA in some individuals and alarge number of extra copies in others. Individuals with alarge number of extra copies- knownn as the "long repeat" version of TOMM40- coupled with ApoE3 develop ALzheimer's an average of seven years earlier- at about 70 compared to the individuals have the "short repeat" version.

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A Japanese scientist at Princeton University has done work since the 1960's to show that increased level of carbon dioxide lead to increased temperatures on the surface of the earth. Syukuro Manabe at Princeton was honored for this work with the Nobel Prize in Physics. Also honored is a German scientist Hasselmann who showed the connection between weather and climate with his own model. His research shows methods for attributing various impacts on climate of human activity and natural phenomena. Also honored is Italian scientist Parisi for his work on complex systems uncovering patterns in disordered complex materials.

Today's understanding of how the use of coal and other fossil fuels at the scale done in China, Europe, US and India is affecting the climate comes from the work of these three scientists.

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Independents make up the largest voting bloc in Arizona. Mr. Biden swung 60 precincts to win by 10,000 votes in 2020, and did well with independent voters. NYT looks at the situation in Arizona for 2024. Much depends on Maricopa county which includes Phoenix. About 60% of Arizona votes are in Maricopa county. Other states which are closely contested are Pennsylvania, Wisconsin, Georgia.

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Elections in Nigeria on February 16 are seen as a referendum on president Buhari's first term. 84 million voters will chose who will lead Nigeria, Africa's largest democracy. The choice is between Mr. Buhari and Mr. Atiku Abubakar, Mr. Buhari won office in 2015 with his All Progressive's Party on three promises of ridding Nigeria of endemic corruption, fixing the economy, and tackling security issues. The economy entered a recession and then climbed out of recession under Buhari. Mr. Atiku plans to privatize parts of the state owned oil company, a plan which has been received with some skepticism considering problems with privatization around the world. A remarkable aspect of this election is that half of registered voters are aged 18-35, who see their leaders as out of touch. In fact many are supporting a "Not Too Young to Run" campaign to encourage younger people to run. 2015 was the only time Nigeria had a peaceful transfer of power since civilian government was installed in 1999. The candidate with the most votes is declared winner if they have at least one quarter of the votes in two thirds of Nigeria's 36 states and the capital Abuja. Nigerians look for someone who will unite the country as the  democratic process is only now being popularized and planted in Nigeria. This is not an overstatement as Nigeria has Muslim North and Christian South, and 200 ethnic groups.  ...

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Stefanos Tsitsipas plays Novak Djokovic in the Australian Open final.

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The U.S. National Security Adviser Jake Sullivan, says that it is imperative that the WHO report on the origins of the virus be "independent" and "free from alteration by the Chinese government." This echoes earlier concerns of the Trump administration and of president Trump who made the decision to quit WHO on this issue.

Sullivan noted that "reengaging with the WHO also means holding it to the highest standards. We have deep concerns about the way in which the early findings of the Covid 19 investigation were communicated, and questions about the process used to reach them."

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A car the early postwar Fiat model 500 which sold 4 million cars for this one mode alone, sold 57000 cars in its new version 50 years later motly on national sentiment in Italy. This is happening in the backdrop of new small cars that are coming up at really low prices in countries like India where the Tata model is expected soon. However this Fiat is being marketed in mature markets like Europe and soon in North America. Is Fiat overlooking the huge Asian market? Interestingly costs are lowered by sharing a Polish factory that makes this car and the Fiat Panda to also make Ford's Ka model.

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Pictures from DW.com of the first days of Autumn in Germany.