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A Phase 1 trial of over a thousand volunteers shows the Oxford vaccine works well with minimum side effects that can be handled with acetaminophen. Phase 2 trial is underway with volunteers in UK, Brazil and South Africa. Participants given the vaccine had significant increase in antibodies to neutralize the disease, and T cells for long term protection. About 70% reported fatigue or headaches which can be handled with acetaminophen. After the Ebola crisis of 2014 in West Africa the British government invested 120 million pounds to form a group to develop vaccines for top 10 likely threats dubbed "Disease X." On this list was the coronavirus. Scientists at the Jenner Institute at Oxford formed a team as part of this effort. Sarah Gilbert and Adrian Hill led the scientists at Jenner and pioneered research for  a new way to do this- to first replace a part of the virus with a component of the new virus. Then to remove the part of the virus that allows it to replicate in humans. This method is called recombinant adenovirus vector. The Oxford scientists used existing technology in new ways to increase the chances of getting a good vaccine early.  The first vaccine could be developed and tested for mass production by September. A 30,000 participant trial begins in U.S. in August. About 1 billion doses could be manufactured by end of 2020. India's Serum Institute has the manufacturing facilities to do this near Pune, India.  ...

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Tim Cook talks to developers at a world wide virtual and in person event. 

Apple will introduce a new 13.5 inch Macbook Air with a inhouse M2 chip for $1195 on sale in July 2022. A new 13 inch Macbook Pro will also be made.

The new iPhone with 5G capability had sales of $191 billion in fiscal year ending in September 2021. iPhone sales up 6.2% in 2022 vs 39% in 2021 when the pandemic led to remote work on Apple and other PC's.

App store and ad sales up by 17% to $80 billion, larger than Mac and iPad sales. 

Apple Pay will break payments into 4 installments as an option. Messages will have an unsend or edit option for 15 minutes.

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The B.1.1.7 coronavirus variant from UK has changed the level of vaccination needed to where life returns to normal, says the Pasteur Institute in France. The level of vaccination has to be higher than the 70% or 80% earlier thought  to be needed for people over age of 18, in the range of 90% now that more infectious variant spread is happening. This also means social distancing and mask use, healthy foods and habits of exercize remain vital.

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Third quarter growth in the European Union was 12.7% higher in the third quarter of 2020 than in the second quarter. The decline from coronavirus was 11.8% in the second quarter. The French economy growth was 16% after a decline of 13.8% in the second quarter. The second wave of the coronavirus could lead to a smaller contraction this time of 3-4% for the quarter because the lockdown is partial and companies will continue operating.

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There are 100 vaccines being developed all over the world, of these 30 are in India. One is a collaboration with Britain for the Oxford Astra Zeneca vaccine to be produced largely in India. The other is one by ICMR. Other vaccines are the Johnson and Johnson  one dose onl vaccine. These vaccines have the advantage of not requiring ultra low temperature storage. 

Even though the Pfizer BioNTech vaccine is off to a start in Britain this does not mean that the other vaccines are not going to be out soon as early as by the end of December. There is also no clarity on how long the protection lasts. More than the one billion doses of the Pfizer vaccine will be required making the other vaccines just as or even more important. Asia and Latin America, Africa are still not in the picture and will have to be for the protection to be effective.

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People have to take charge of their own lives by eating healthy food and lots of fruits and vegetables, to reduce obesity in this pandemic. Studies show that people with obesity were twice as likely to end up in hospital, and 74% more likely to end up in intensive care. Efforts to rid our diets of sugary drinks and junk or processed foods need to be escalated, and exercize, walking, cycling, other activity need to be made part of our daily activity. This needs to be taken up as a fight for life, a war against decades of neglect and reckless behaviour in eating habits.  Even vaccines will not work well when body mass index BMI is over 30. Obesity has reached unbelievable and scary levels - 66% in the UK, U.S., high in the Middle East, and increasing all over the world. Added risk is high smoking levels in China and India. Coca Cola takes the place of water in parts of Mexico where obesity is high and Mexico has suffered from high coronavirus cases. ...

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The longest serving senators as Majority Leader includes Joseph Robinson Democrat of Arkansas who was Minority and Majority Leader form 1923 to 1937 and helped put the New Deal of Franklin Roosevelt through the US Congress. That role is also being played by McConnell and now Thune in this period of change in the 2020's with cyber security, tech monopolies, pandemic and cost of living issues.

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Redistricting in Texas that may flip 5 Democratic seats in US Congress to Republicans. With population shifts to the south Texas has grown in population in 5 years to 2025 by roughly 2 million from 29 million to 31 million. In 2025 about 40% are Hispanic and 40% White evenly divided, with 11% black and 6% Asian, and 3% other. It remains a conservative state in the South with a focus on faith and on traditional values. Along with Florida and the two Carolinas it remains a major part of the Conservative South.

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Tesla which had 11% of the new electric cars registered in 2024 through July, suddenly goes into free fall with registrations dropping to 3% and a 33% decline in the European EV market. From being second only to VW in EV market in Germany Tesla is not with a model even in the top 10. Tesla had got the support of the Scholz government to put abig factory near Berlin. Tesla CEO Musk's politics is having some impact with endorsement of the AfD by Musk seen as interference in German elections. The Tesla Y is priced at $74,000 another hurdle for buyers. And now there are many rivals from Germany and China. In an expanding market Tesla has lost 60% in registrations in first half of 2025 showing how deeply. BYD of China has a entry model Dolphin Surf for $20,000 in Germany, and has increased sales by 290%. Still Chinese car makers will only have 12% of the EV market and it is VW that is a winner in the competitive market in Europe. VW has ID.3 Pure for under $30,000 and in 2026 plans ID.2 Pure for under $25,000. ...

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The growth in U.S. GDP was 1.7 % in 2011, yet unemployment dropped by 0.7% in the last 12 months to 8.3% by Feb. 2012. A pickup in hiring is seen in job figures. Christina Romer gives as an explanation to the rise in unemployment in 2009 to 10%, more than expected, and the drop since then, to the overreaction of companies to the financial crisis by laying off workers and freezing hiring- with hiring picking up as conditions return to normal levels. The unemployment rate as defined is also not an accurate measure of the jobs situation, as it reflects only workers who are looking for work, and many workers drop out of the jobs market when they are discouraged especially the long term unemployed. Taking into account people who have dropped out of the labor markets the unemployment rate was 11% in Nov. 2009, according to Luce in the Financial Times- in Ezra Klein, Washington Post 12/12/2011, Wonkbook: Real unemployment rate 11%. Lawrence Katz, Harvard Labor economist also cites this as one of three jobs crises in unemployment today that need to be addressed, the other two being: foreclosures and debt, and the low number of jobs added because of automated manufacturing- in Friedman, NYT, 12/10/11, The Next First 100 Days. Explanations for the low GDP growth as unemployment declines is a likely productivity slowdown. Prof. Robert Gordon of Northwestern University, sees a slowdown in productivity. Worker output for every hour worked, how productivity is measured, increased only 0.4% in 2011 and 0.9% in the last 7 quarters, and is trending downward in the longer term. A more likely explanation is that unemployment is still at higher levels but is understated in unemployment figures....

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About 80% of Swiss voters supported the 15% corporate minimum tax that will bring an additional 2.8 billion dollars in tax revenue. If the Swiss had not backed it, the additional revenue from lower Swiss taxes of about 11% and the 15% would have gone to other countries. The Biden administration and many EU countries have considered this one of the most important achievements for fairness, and to support much needed state spending in their countries to maintain the quality of life.

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Omicron cases are up in an almost vertical line on a graph with cases doubling every 2-3 days in the UK, similar to the pattern in South Africa during the beginning of the spread in South Africa. Since then early data in South Africa show the trend in the province of Gauteng, center of the omicron outbreak in South Africa in the Johannesburg area, has reached its peak. On Dec. 16 it recorded 27% of national infections compared to 70% the week before. Head of the National Institute of Communicable Diseases in South Africa, Michael Groome, says "we had areally dramatic increase in Gauteng, which has now leveled off."  Hospital admissions in South Africa show a different pattern than earlier hospital admission rates in previous waves, with only 1.7% of cases being hospitalized in this Omicron wave compared to 19% for the Delta variant wave at a similar point in the wave, says Health Minister Joe Phaahla. In UK as of Dec. 14, this WSJ report cites health authorites saying 73% of cases in London are omicron variant, doubling every 1-2 days, with omicron making up 41% of all cases in England. In the US the Centers for Disease Control show Omicron variant making up 2.9% of all cases in US as of Dec. 11, with highest concentration in New York, New Jersey of 13.1%. Proportion of positive tests went up from 3.3% to 5% in New York City. A convention in New York City, Anime convention at Javits Center, November 23, 2021, shown in a recent NYT report, could potentially have acted as a super spreader event in New York according to NYT though not confirmed, similar to football stadiums events in Italy in March 2020. Dense atmosphere and large crowds increase the risk of a super spreader event happening, say experts. ...

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The rotting carcasses of the minks that were culled will be dug up to be incinerated. Environmental inspectors found that some water sources might have been contaminated by bacteria. The 17 million minks in Denmark were the target of culling after fears of coronavirus in minks. The whole issue has shown the problems in some of the Nordic countries that were seen as models for healthcare and public services. Sweden's treatment of the elderly in nursing homes was seen all over Europe as shabby and the king of Sweden called it a "failure.

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NYT gives this perspective of Mikhail Zygar on the difficult economic situation in Russia in January 2026 before the Iran War. Putin considering bringing Igor Sechin, head of Rosneft, as negotiator for Russia with Ukraine, to replace Kirill Dimitriev. Dimitriev is seen in Russia as an insubstantial figure and with no real mandate, on the point of being dismissed by Putin. This would being new life to Ukraine negotiations to end the war. This report says if Russia was to end the war it would have to change the structure of power and that included bringing in a new administration to rebuild the economy, to replace prime minister Mikhail Mishustin. He says oil was sold to India in January for $22 per barrel about one third of the market price. The economy was getting severely affected by the war and the conditions it had created for inflation, oil revenues under sanctions, and by financial and human cost of the Ukraine war, a credit crunch and a wave of bankruptcies that were expected in January 2026. Some of this is confirmed by the perspective offered on the same day this article appeared in NYT by an NYT article from the Foreign Minister of Sweden, Maria Malmer Stenegard. Stengard says Swedish analysis shows central bank interest rates set at 21% in 2024 when interest rates were 10%, suggest inflation was much higher than the 5% official figures. The minister also points out that instead of growing by 13% as official figures reported Russian economy had declined by 8% over 2020 to 2024. British government estimate is that the losses from the Ukraine war are $450 billion. Official growth estimate for 2026 is 0.4%. even with higher oil prices. All this changed with the Iran war by February and the jump in oil prices and Putin has decided not to make the changes he thought necessary and wind up the war, considering that some of the objectives had been achieved and to avoid an economic downward spiral. It is now Putin's decision says this report.  In the past Putin has always given the economy and living standards the priority. Yet the elites in Russia says this report are concerned about the fragile nature of the economy as present oil prices may come down in a short period. ...

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As the US central bank, the Fed, considers cutting high interest rates that affect housing costs and mortgages this WSJ report looks at the consumer debt in September 2024. It says consumer debt is at $17 trillion in 2024. This is high except that when inflation adjusted it is only 3% above the consumer debt in 2019, the peak happened in 2008 before the banking induced financial crisis. Then there is the question of what the debt composition is. Here overall debt has grown by 4% yet credit card debt is up 11%, not a good sign when the interest rates charged by banks is 12%, by cards 22%. Households are paying off credit card debt by borrowing from sources with lower interest costs.

This is more evidence why many households are hurting as debt servicing remains as and additional cost of living issue for Americans.

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The Raleign area in North Carolina near the location of 3 research oriented universities is rebounding quickly from the pandemic. It is now No. 3 in WSJ's annual survey of US labor markets with big gains in wags and jobs. This report in WSJ looks at how this was done with business, communities and local government working together.

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The consensus in South Korean society about rules for tackling coronavirus surge are breaking down, because some groups are pushing for keeping the economy free of lockdown and some are pushing for stricter rules as the cases increase once again into the hundreds. Berlin had a big rally of right wing protesters last week showing that the consensus is fraying as tempers rise about the effects of the lockdown, as cases increase and the government is forced to restrict activity and gatherings.

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Changes to a U.S. visa program so that fewer workers would be given visas at the entry level. Instead favoring the higher of four wage levels to give visas to foreign workers. The idea is to bring in more talented workers to the U.S. with less effect on depressing wages in the U.S. by bringing in foreign workers at the entry level as happened before.

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The US death rates were 15% above normal compared to other European countries at 9-12% above normal for the pandemic. The US deaths exceed 1 million in 2020 and 2021. India's death rate was about 26% above normal, Brazil's 24% above normal compared to 41% for Mexico, even though Brazil made the most headlines. Uneven vaccination in states in the northern and southern US led to the high US death rate and 1 million deaths.

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A New York hedge fund Elliott Management Corp. finally makes a settlement with the new Argentine government of president Mauricio Macri. It took 15 years and 5 different administrations in Argentina. Eliott gained $2.4 billion 10-15 times the original investment on Argentine bonds made in 2001, but requiring extraordinary persistence from hedge fund manager Mr. Newman at Elliott Management Corp and Mr. Singer. In 2001 the Argentine bonds traded at 20 cents to the dollar, and Mr. Newman who had made large gains on Peruvian bonds saw this as a good investment. By 2008 the bonds instead traded at pennies on the dollar, and the Argentine government later settled with 93% of bondholders at 30 cents to the dollar. The holdouts were three hedge funds, including Elliott. The Argentine government of Kirchner opposed any settlement with the holdouts. The situation changed with the election of Mauricio Macri in 2015, who made resolution of the issue a priority, so that Argentina could borrow in global financial markets and grow its economy. The U.S. Supreme Court had rejected Argentina's appeal of a U.S. District Court ruling prohibiting paying interest on exchanged bonds when payment had not been made to the holdout hedge funds- which led to the settlement with Elliott, and closing a long and difficult chapter for Argentina....

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The U.S. National Security Adviser Jake Sullivan, says that it is imperative that the WHO report on the origins of the virus be "independent" and "free from alteration by the Chinese government." This echoes earlier concerns of the Trump administration and of president Trump who made the decision to quit WHO on this issue.

Sullivan noted that "reengaging with the WHO also means holding it to the highest standards. We have deep concerns about the way in which the early findings of the Covid 19 investigation were communicated, and questions about the process used to reach them."