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The experience of J&J and Novavax in vaccine manufacturing shows the importance of vaccine manufacturing and of Quality Assurance in the production of vaccines for coronavirus. The success of Pfizer and Indian companies in vaccine manufacturing shows how important it is to think early and plan early for vaccine manufacturing technologies, personnel and quality assurance. This is also why the US effort, India's billion vaccine target in 6-12 months of planning, is a great effort in thinking ahead of every aspect of vaccines and vaccinating, planning of all details, hard work, by Pfizer, by Indian pharmaceutical companies, and by the Modi and Biden administrations. 

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With the hype around AI and the propagandizing by people like Altman, Microsoft, and others AI got to the point where it made up 34% of the S&P 500 capitalization, and all time high for 7 of the large companies since 1980. Nvidia who makes the chips for AI  making up about 6.8% of the S&P 500, contributing to a quarter of the total return on the S&P 500 index in 2024.

Till someone in China figured out a way to do it at 5.6% of what it costs in the US for the high flying AI companies in the US. 

 

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A company that was close to insolvency in 2020 and which is loss making will be the largest float in the London stock market in 2021. The food delivery app Deliveroo will have a valuation of over $8 billion. It shows how investor capital is being drawn into businesses in a wildly disproportionate way leaving vital sectors such as health infrastructure, national infrastructure and education poorly funded.

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Moderna, J&J, Pfizer in the U.S., Sanofi in France, AstraZeneca in Britain, have accelerated their efforts to have a vaccine ready by the fall.  Moderna and Pfizer use new technologies. Astra Zeneca is working with Oxford University on a vaccine that builds on existing technologies. Both AstraZeneca and Sanofi are building capacity to make hundreds of millions of doses of the vaccine. 

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The coronavirus health crisis with people staying at home in a lockdown has shown the tremendous potential for telemedicine. It has revolutionized the medical profession as more patients are treated over the phone or video app discussing symptoms in a virtual visit and treatment, when the situation is minor or not critical. A urology doctor discusses the potential for using telemedicine in his field and many other medical fields.

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Apple CEO Cook apologizes for the problems with the Maps feature in the iPhone 5.

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Asia's longest bidirectional tunnel is between Ganderbal district in Kashmir and Kargil district of Ladakh in India's Himalayan region at a height of 11,500 feet for 14.2 kilometres. Indian Express shows pictures of work on the tunnel which will cut time across the mountains from 3 hours to 20 minutes and connects Leh in Ladakh with Srinagar in J&K providing all weather connectivity. It will be completed months ahead of completion date of 2026. As part of the project 19 tunnels are being constructed at a cost of $3.5 billion.

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By lifting all covid restrictions China makes a dramatic U turn in December 2022 from its zero covid policies. This Guardian editorial looks at the implications of the new policy. Testing booths are being dismantled. Quarantine rules and travel restrictions are significantly relaxed. The primary covid tracking app is scrapped.  The turnaround is truly astonishing in its speed says The Guardian. Because older people are less vaccinated than in other countries and the smaller effectiveness of domestic vaccines this still has risks when it is being done so suddenly that the health system has little time to prepare.

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With occupancy declining to below 76% on many of the downtown San Francisco buildings the value of this is decliining fast. The Embarcadero Center that once defined the downtown area is now on sale for $90 million, according to the WSJ report, down from $245 million that was paid for it in 2018. Owners of these office buildings in San Francisco are liable for payments on $12 billion in bonds, according to S&P Global. Half of the stores in the Union shopping district have closed and Amtrak ridership is down 61% over 2019.

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India's Finance Minister Nirmala Sitharaman says the decline in the auto sector sales includes as one of the factors the shift by millenials to ride sharing app services such as Uber, Lyft and Ola. A bigger factor is the lack of financing as less credit is available with bad loans hitting the banking industry. The current economic slowdown in India includes a drop in sales of automobiles.

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The use of apps and tech based solutions have been largely ineffective in doing effective contact tracing and testing to isolate people with coronavirus. Epidemiologists question its effectiveness when it does not lead to people isolating themselves to prevent spread.  A major problem is lack of confidence in the tech based solutions. 27 states in the U.S. have no apps or are not developing one.  Apps do not use the entire set of tech resources available because of dilution from concerns about privacy. Another major problem is that there is no national approach. California, Washington and Oregon have a pilot program on the Google-Apple system, Delaware and Pennsylvania launched an app in September from Irish developer NearForm. New York and New Jersey started with a NearForm app in October. States using apps are doing this without much conviction that this is a tool that will work to do effective contact tracing and testing to isolate infected persons. For this reason one sees pilots and launches this late in the coronavirus pandemic. Early efforts stumbled.  The UK and French apps also proved ineffective. Germany opted for low tech solution that proved surprisingly effective in the first wave of the coronavirus. Germany relied on teams from state employees which used a national database, personal computers and phones to call individuals who needed to be isolated and tracked. Asian countries have less concern for privacy leading to apps being more effective. Even here low tech solutions with national database and teams of people with personal computers and phones calling and making personal contact including visiting homes has worked better than apps. Human relations skills to reassure people affected by coronavirus, legwork to contact personally at homes and check up, and persuasion to have people isolate have been more effective than app based impersonal tech solutions. ...

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In the March 29, 2009, local elections in Turkey the AK party led by Mr Erdogan got only 39% of the vote down from the 47% it obtained in the 2007 general elections. Unemployment is 13.6% and the Turkish currency's value dropped, and GDP is declining. Mr Erdogan's claims that the global meltdown had not touched Turkey irked voters, and other local issues and parties also resulted in a loss of support. Erdogan is seen as aloof and losing touch with the people compared to the years when AK was on the rise.

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America's nonfinancial companies are sitting on the biggest cash pile ever- $2.1 trillion at the end of June, according to Moody's Investors Service. AT&T has $15 billion in cash. And Delta Airlines is in a better position to survive the pandemic with $15 billion in cash.  Companies in STOXX Europe 600 have also posted a similar rise.in cash. Liquidity ratios are up at Deere and Southwest Airlines.

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The dominance of trillion dollar companies, Apple at $2.4 trillion and Microsoft at $2.1 trillion, which make up 13% of the S&P 500 index during the regional banking crisis of 2023. The index was up 3.5% in March even as some banks were shut down by the FDIC. This has given these two companies the role of a safe haven in the crisis, along with chipmaker Nvidia. Not for the tech sector's other companies such as Google, Amazon, Facebook and others which are companies facing monopoly behaviour scrutiny and possible breakup by the Biden administration and Congress.

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A sign of irrelevant factors intruding into political discourse is this lawsuit challenging the TikTok ban in Texas saying that it prevents academic research. TikTok as a social media app was never known for its use in academic research. A lot has been written about its harmful effects on teenagers. The Knight First Amendment Institute at Columbia University filed this lawsuit making this bizarre, as it brings a large east coast university into this discourse, that does nothing to address the harmful effects of social media when two thirds of fourth graders in the US are not proficient in reading.

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There is a clear difference between Biden and Trump on the Climate. Biden put the US back into the 2015 Paris Climate Change Treaty in fight against climate change after Trump took the US out of it. Trump supports coal and oil & gas. Biden is working to phase out of coal and fossil fuels in a way that still keeps the economy strong. There is place where the difference is so starkly clear. Expect climate change events, storms, fires, floods to grow under Trump, and storms, fires and floods to be made to recede under Biden with strong climate change action.

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The story of Zhang Yiming of TikTok. He founded the App in 2012 in Beijing. His first app was Jinri Toutiao, translates to Today's Headlines. And came up with the idea of feeding people more of what they have read. This is the beginning of how today's echo effects of the news people read and opinions that are shaped in the process being one sided without any dialogue or mixing with others. This is not good for demcoracy and the dumbing down in social media adds to the lack of literacy. In the case of this China based app it means 170 million Americans are spending time in ways that deplete not add to cultural literacy. Some of the same arguments operate for social media as X and other social media divide rather than bring people to exchange views and thinking for better understanding and education.

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Swarnalatha Reddi is a part of a young generation of Indian women engineers joining industry. Click on Original Article to see this video of how Chennai is becoming the world wide hub for electric vehicle technology and manufacturing. Shown here are Swarnalatha as a new e-mobility engineer from a neighboring state who moved to Chennai's Mahindra R&D division. Senior managers at Mahindra and BMW say that the local government is paying particular attention to needs of manufacturing in Chennai.