LyrArc Article Gist
Millenials are moving away from political parties to look at individual candidates in 2014. Attitudes are changing moving away from gender politics. A Pew Research Center survey of March 2014 shows 50% of millenials consider themselves political independents. And 31% believe there is not much difference between Democrats and Republicans.

LyrArc Article Gist
German born Joerg Reinhardt, the new chairman of Novartis, is overseeing the plan to revitalize and strengthen its R&D operations. Reinhardt who has a doctorate in pharmaceutical sciences, spent 30 years working for Novartis and its predecessor company Sandoz, before leaving for Bayer in 2010 and returning to Novartis. He is leading the effort by setting up a board subcommittee setup to oversee the research and development effort. The new subcommittee's task is to review the R&D strategy and organization. The subcommittee will advise the board on scientific trends and activities critical to R&D success. Novartis has increased R&D budget to 5.6% in 2013, which will remain at that level in 2014. The pharmaceutical industry by contrast decreased spending by 2.2% in 2013 compared to the high point in 2011, according to PriceWaterhouseCoopers. Research activities will be concentrated in 4 cities- Shanghai, Basel, Boston and La Jolla, California, to take advantage of infrastructure already in place in these places. A review of Novartis's portfolio of business begun in 2013 will be completed in 2014. Reinhardt says acquisitions of upto $5 billion could be made to build scale for promising smaller units. The review also includes Novartis's one third stake in Roche built up since 2001, and conversations Reinhardt is having with Roche's new chairman Christopher Franz....

LyrArc Article Gist
When the coronavirus spread in China it was expected that Taiwan would be affected badly. Yet Taiwan has managed the situation in a number of ways that has limited cases to 50. Health experts attribute this to quick preparation and early intervention. After the 2002 and 2003 SARS epidemic Taiwan setup the National Health Command Center (NHCC) to combine resources for managing a health crisis. This was to prepare for the next crisis. Taiwan acted early imposing a ban on travel to China, Macau and Hong Kong, and a ban on the exporting of surgical masks to keep a stockpile in Taiwan.  Taiwanese government integrated data from national health insurance with immigration and customs data. A program was developed  that allowed people to report travel histories and symptoms by scanning a QR code when they arrive in Taiwan. Travelers receive a text message with their health status that allows customs officers to focus on the ones requiring attention. The public's willingness to follow government regulation is now much higher after the difficulties caused by the SARS crisis. This makes them willing to follow more readily action taken by the government, as SARS memory is still fresh in their minds. Investments in public health systems and in biomedical research is much further advanced than in other countries. A research team at Academia Sinica has developed antibodies that can identify the protein that causes coronavirus, The aim is to shorten the test time for diagnosis to 20 minutes. The lead researcher Yang says the next step is to validate it before turning out a rapid test kit. ...

LyrArc Article Gist
David Blanchett, head of retirement research at Morningstar Investment Management, William Reichenstein, Powers Professor at Baylor University, Guyton at Cornerstone Wealth Advisors in Minneapolis, and Hebeler, former head of Boeing Aerospace (who does dissemination of free sound financial planning at www.analyzenow.com), provide a better understanding of the issues involved in making good retirement planning decisions and the thinking needed to avoid errors.

LyrArc Article Gist
The Naval Innovation and Indeginization Organization of the Indian Navy, NIIO, sets. a new pace and direction for the Indian Navy and its mission in the Indian Ocean. The goal is to use the idea of the Gati Shakti plan to bring together industry, academia, research organizations, government in partnership for adopting 75 indeginized innovations in a few years. In the last year 54% of the Indian defense budget was given to companies within India for product and services, and in the coming year the plan is for it to go up to 70%, according to defense minister Rajnath Singh. This means even aircraft carriers will be be developed and built in India at Indian shipyards using Indian technology.

LyrArc Article Gist
David McCoullough, dies at 89 years. He is the author of two best selling biographies of American presidents at crucial points in the American experiment on Harry Truman (1992) and John Adams (2001), for which he won 2 Pulitzer Prizes. He also won the National Book Award for- Path Between the Seas- the Making of the Panama Canal. He saw writing as painting in words, and writing as an art form, did extensive research so that his Truman book took 10 years, the Adams book 7 years. 

LyrArc Article Gist
Two U.S. botanists coined the term "plant blindness" for the inability to see or notice the plants in one's environment. Limited interest in plants leads to an under appreciation of plants and their value in environmental health and in medicinal research.

Plants and trees are essential to an healthy urban environment. And 28,000 plant species are used for medicines of great value for health. This BBC article looks at the ways humans can increase their exposure and awareness of plants and green environments around them.

LyrArc Article Gist
US Universities awakening to the need to reduce costs after making college unaffordable to middle class. NIH says indirect costs are in the range of 60-70% at some elite universities, the proposal would cap this at 15% for all universities for federal funding. The purpose is to reduce administrative costs that are increasing and have universities take a hard look at finances not just increase salaries, hire more and increase prices for students to go to college. The savings generated could be $6.5 billion in this one action alone and some universities need to cut salaries and hire less to bring down their cost structure before a whole generation of young men are deprived of opportunities to go to college. Not everyone can be sent to apprenticeships and not all research needs to be funded. China and India and some European nations will be funding the same research with less. There is a Deepseek moment now not just for AI - for all research.

LyrArc Article Gist
Washington Post reporters Clement and Gushkin with research and polling experience at Pew Research Center give the results of the Post-ABC News poll taken before the State of the Union 2023 address by president Biden. It shows what president Biden has said about his  investment spending of trillions of dollars in America's crumbling infrastructure, in new manufacturing for chips, advanced technologies, R&D, electric charging stations, EV vehicles, renewable energy. "Folks we are just getting started." The investments are taking place quickly because today there many projects ready for investment. Yet it takes time for the manufacturing plants to be built, new expressways and bridges to be built. The poll shows not enough people know- only a third of people know about two thirds do not know. That Mr.Biden is aware of this is apparent. He says-"It is one thing to have passed it all- now we have to make sure we're on it every single day. Not a joke." And on Jan 26, saying "Implementing it so people can see what we've delivered and give it to them directly."  This is why president Biden used his State of the Union address to make the points directly to the American people. This is also seen in his recent speech to a union audience when he told workers- Mr. Trump used infrastructure as a punchline, Biden turned it into a decade only headline. Creating well paying jobs and doing this while cutting the deficit by trillions of dollars. To give the contrast Mr. Biden told workers and working families the spending cuts proposed by the Republican House of Representatives were according to Moody's likely to result in a loss of 780,000 jobs.    ...

LyrArc Article Gist
Special Counsel Robert Mueller issues an indictment of 13 Russians on Feb. 16th, 2018. The indictment was made public by deputy Attorney General, Rod Rosenstein, at a press conference. President Trump says the Internet Research Agency in Russia started its activities in 2014 long before he announced his bid for the presidency, and now acknowledges the Russian activities in the U.S. presidential election of 2016.

LyrArc Article Gist
India is a founding member and lead chair of Global Partnership on AI. At the GPAI Summit at Bharat Mandapam, New Delhi, December 11, 2023, prime minister Narendra Modi talks about India's potential  for cutting edge research and also about the risks and dangers of AI. "AI is transformative. Yet its transparency is essential, data and algorithms have to be transparent, and free from bias, for its right beginning, to be useful to humanity." Modi describes the useful aspects of AI for India's health sector and for other sectors, and India's UN Sustainability Goals. The safe and ethical use of AI and its democratization with AI for All a focus in India.

LyrArc Article Gist
Millenials group ages 18-49 who have decided to have zero children post pandemic is growing, as shown in this story in The Washington Post- with many graphs about what is really happening. A 2021 Pew Research poll shows 44% of childless adults ages 18-49 saying they do not want kids, or are not likely to have kids. This is up from 37% in 2018. And 56% of these people simply give no reason, just that- no kids. The difficult economic environment is part of this, so is the difficulty in raising kids that do better than their parents, the huge resources needed to raise good kids, all leading to this view among millenial women.

LyrArc Article Gist
Spencer Silver working in 3M labs in Minnesota found a rubbery substance that left no residue and held two surfaces together, It took 10 years before he found a use for it. Most inventing starts accidentally and the use is only found later sometimes taking many years. This is the story of inventing in America and Europe for the last 300 years. This is true for Medicine discoveries happening by accident. It is time for America to return to inventing and investing in its labs and long term research. Efforts which will bring results in improving medicine, health and quality of life. Too much time and resources have been invested in the wrong places for short term results.

 

LyrArc Article Gist
The US reached the moon 50 years earlier in 1972 in the Apollo lunar mission. The new launch was done by a vehicle developed by Houston based Intuitive Machines. It is carrying NASA research devices under a $114 million contract. Lunar landings are difficult because of the thin atmosphere and need to slow down rapidly to land. Intuitive Machines spacecraft was brought down to speed of 3 feet per second before landing. It has one week before lunar night makes it inoperable. A similar landing was accomplished recently by an Indian spacecraft by large drops in speed to achieve a stable landing, after an unsuccessful earlier attempt that did not achieve the drop in speed required for landing.

LyrArc Article Gist
Research by Allen Roses, director of Duke University's Deane Drug Discovery Institute, and continuing research on the ApoEgene that has aclose link with Alzheimer's. In 1993, Dr Roses's research showed that people who have avariant of the ApoE gene have an unusually high risk of developing Alzheimer's. THese studies have been repicated by other scientists. In research presented at the international conference of Alzheimer's deisease in Vienna, Dr Roses and this team show that they have found a gene linked to ApoE called TOMM40. This gene had mutations that involved a small number of extra copies of aparticular building block of DNA in some individuals and alarge number of extra copies in others. Individuals with alarge number of extra copies- knownn as the "long repeat" version of TOMM40- coupled with ApoE3 develop ALzheimer's an average of seven years earlier- at about 70 compared to the individuals have the "short repeat" version.

LyrArc Article Gist
Barry Schwartz, a Psychology Professor at Swarthmore College, and author of Paradox of Choice: Why More is Less, points out that the 35 years of research shows that you get exactly what you pay for, but it turns out to be the opposite of what you want, and there are a lot of ways that incentive based compensation can go wrong. In theory choosing a parameter like share price and creating incentives to promote shareholder interests through higher share price as a measure of executive performance is reasonable, but it assumes that there is no manipulation of share price, or other external factors do not distort the measure of performance. In reality you get a situation like Merrill Lynch and other financial firms that gave out huge bonuses and executive pay even while bad decisions- that were later to sink the firms- were being incentivized. Schwartz points to research worldwide by Bruno Frey, Oberhozer-Gee, Uri Gneezy, James Heyman and Dan Ariely, that shows that incentives tend to remove the moral dimension from decisionmaking. Heyman's reaearch showed that when people offer passers by a token payment for help lifting a couch from a van, they are less likely to lend a hand when they are offered nothing. The question people ask themselves he says when money isn't part of the equation is very different he says: what are my responsibilities, what should I do that will fulfill these responsibilities to other people and to my country? In his view even though we put a lot of faith in incentives as a society to influence behaviour in a positive way, they actually do the reverse. Even if they work for some time, after a while some people who have fewer scruples learn ways to game the system and gradually distort the way it functions, leading to perverse results endangering all....

LyrArc Article Gist
It says a lot about America at this time in 2025, and should be reassuring to all that these women are standing tall in their effort to do this- to pursue satisfaction of contributing to national life and professional lives, and being good parents involved in raising children. Shown in this report in WSJ as examples of Conservative Women are Alabama Senator Katie Britt 43 years, May Mailman deputy assistant to the President, and ,Shannon Clark. Other women shown are former North Carolina governor Nikki Haley,  Karoline Leavitt, press secretary to the president, Huckabee Sanders, governor of Arkansas. They all say their faith, grit, family and spouse, and setting priorities, are helping them both make it in their careers and be engaged parents at the same time. Pew Research shows of women in both parties Republican and Democratic, about 70% want careers outside the home, and about 88% want good parenting at the same time.   ...

LyrArc Article Gist
The Observe Research Foundation looks at Sri Lankan debt crisis.Too much borrowing at high interest rates above 6%, without concessionary loans typical of what developing countries need, can create havoc for poor countries such as Sri Lanka. When macroeconomic factors collide with health and politics such as drop in remittances, global financial crisis of 2009, civil war, borrowing for unsustainable type of infrastructure such as ports and airports, the results can be disastrous. Sri Lanka is an example. Borrowing that is off the official record of loans such as to state owned companies can leave the country with higher debt load than even the Finance ministry has kept track of, a severe problem for small developing countries, including countries  in the Caribbean shown in recent NYT reports.

LyrArc Article Gist
The Guardian looks back at 2023 and covers the work of scientists from US, Germany and Brazil showing the damage. NASA scientist James Hansen tells The Guardian that with the current stage of politics and inaction on climate change young people in the world need to take over. Scientists at the Japan Meteorological Agency measured temperatures at 0.53 degrees centigrade higher than the global average 1990 -2021. This was higher than the previous high reached in 2016 of 0.35 degrees centigrade. Over the long term the world is considered to be 1.2 degrees hotter than preindustrial times, by experts. Included is the report "Hothouse Earth" by the Potsdam Institute of Climate research and other experts on the speed of the global warming.

LyrArc Article Gist
Strategic siting in renewable rich areas (Dallas center the largest is in renewable rich area) and fair cost allocation to not burden small businesses and households are major issues in Data Center building. Data centers for AI -rows and rows of servers 5000 in hyperscale data centers- used 4% of the US total electricity use in 2024. This is growing rapidly. By 2030 this is expected to grow by more than double, by 133%. About 60% of this to power the servers and 30% for cooling the servers. About a third of these servers are located in Virginia, Texas and California. How will this affect Cost of Living concerns, affect electricity prices? Carnegie Mellon working with North Carolina State University did the modeling on the energy and emissions implications of data center buildup in the US in their Open Outlook Initiative. A 8% annual increase in electricity prices is expected on average and as high as 25% in Virginia by 2030.  Total of about 40% increase over 5 years. Between 2014 and 2024 10 year period average cost for a home electricity use went up 25% from $114 a month to $142. This would now go up by 40% to about $200 by 2030 in just 5 years significantly impacting cost of living in the US. In which states will it strain electricity grids? In 2023 data centers consumed 26% of the total electricity supply in Virginia. In North Dakota 15%, Nebraska 12%, Iowa 11%, Oregon 11% according to Electric Power Research Institute. What are the energy types used? Natural gas is used for 40% of the data center electricity, wind and solar 25%, nuclear 20% and coal 15%.   ...

LyrArc Article Gist
Ms. Claire Goldin, labor economist, wins the Nobel Prize Economics for her work on gender gaps. Claire Miller of NYT looks at the research done by Goldin that shows how women starting out from way behind in education, work and professions have caught up in education and are working in different careers and not letting marraige affect their work. Women Goldin says are now not having the same pay and opportunity only because they cannot work long and inflexible hours men do.Goldin points out that the 1940's period of women growing up missed out on opportunities but generations after that and after 1960 have pursued opportunities that were opening up with time saving appliances at home, Roe vs Wade, and Equal Pay legislation. 

LyrArc Article Gist
A new study using ECB data by the German Institute of Economic Research shows rising inequality in Germany. The 45 richest households in Germany own wealth equal to the bottom half of the population- each group owning 214 billion euros in assets in 2014. The wealthiest 5 percent of the people in Germany own 51.1% of the country's wealth. ECB numbers are underestimating the inequality by showing that 5 percent control 31.5% of the wealth in Germany. The Institute's analysis shows Germany is worse than Spain and France when the wealthiest household's wealth is taken into account. 

LyrArc Article Gist
Israel outlined its own proposals for a nuclear agreement on April 6, 2014. Israel's Intelligence Minister Yuval Steinitz, says any deal must include Iran cease all nuclear research and development activity, remove its enriched uranium stockpile from the country, reduce the number of centrifuges to below what was agreed to in the outline that emerged from talks with Iran in April 2015, closing of the underground facility at Fordow that was built clandestinely in the early 2000's. Steinitz said- "The deal has to be made on the assumption that Iran might violate it."

LyrArc Article Gist
How do you setup a vaccine business. Consider Mr. Adar Poonavalla in the city of Pune in India. His company Serum Institute of India, remains family owned. Founded in 1966 by Cyrus Poonavalla, it produces billions of doses of vaccines for measles, polio and other diseases. It is expected to be one of the key sources of vaccines because of its expertise and the stocks of vials and other supplies that it has in stock for the next 2 years of vaccine production. It is working on a separate facility for coronavirus production that could turn out 800 million doses of vaccine at a price of about $13 a dose over 2 years. Serum Institute is working with 3 companies that are doing the research on the vaccine for coronavirus in the U.S. and Europe, and will play a key role in the manufacturing of vaccines. To respond to the question how do you setup a company to produce vaccines for the people of the world. This is what Mr. Poonavalla says- he will only work with ethical long term funds and sovereign funds because he does not want to be in the situation where he has to charge high prices to give them returns. Unlike most countries in the world, India is unique in making certain that most of the basic pharmaceutical drugs are available to over a billion people at a low cost. Serum's goal is low cost quality vaccine production so that over a billion people in Asia can be "protected from the birth onwards." As the U.S. and Europe and large parts of Asia, Africa and Latin America, face the second vaccine phase of the coronavirus response following difficulties in PPE, Ventilators, and Masks in the first phase, they can have confidence because of companies such as Serum and the research centers in U.S. and Europe like the one at Oxford University. ...

LyrArc Article Gist
Such realism is needed today to listen to all so that climate change action on auto carbon emission can be de-politicized and realistic plan can be adopted. Too many floods, fires and adverse events by 2024 for the US not to have a plan and deny climate change does not exist. The Biden administration gives flexibility to automakers to meet auto carbon emissions rules by 2032 by accelerating the progress in the last 3 years as the capital investments, research and learning curve for new technologies, manufacturing improvements and cost reduction, and charging station infrastructure enlargement have taken place by 2030. Biden administration officials clearly understand resistance of carbuyers when the charging stations needed do not exist and costs are high in 2024, and EV technologies are at learning stage.