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How the discount drug programs at the big drug store retail chains like CVS. Walgreens and Walmart are leading to increasing competition and lower prices in generic drugs that are now sold for one month supplies for hundreds of unbranded drugs. Mass mechandisers like Target have their own programs selling drugs in the same manner as the Walmart which started this with its $4 generic prescriptions for one month supplies in 2006. Its changing the landscape for drug pricing gradually and will become part of a larger trend as health care costs are challenged in different ways by customers, merchandisers, and others in a low inflation cost conscious economic environment, with an overstretched indebted consumer looking for ways to cut costs on everything from groceries, shopping needs and prescription drugs.

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George Rathmann, is the scientist at Amgen who pushed for development of EPO, a hormone which stimulates red blood cell production, when the bio-tech venture company was struggling in the mid-1980's. After approval by the EPA in 1989, Epogen became Amgen's main product with sales of $2 billion in 2011. Rathmann graduated from Northwestern University, and received his PhD. from Princeton University in physical chemistry. He helped develop Scotchguard at 3M, and later headed the R&D department at the diagnostics division of Abbott Laboratories. He built Amgen from a staff of four in the early days in 1980, and it was his intuitive sense that Amgen should focus its entire effort on EPO development in the mid-1980's that led to its success.

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Mauricio Pochettino played for PSG at one time. The Argentine soccer player is now coach for France's PSG as it takes on Manchester City in the semi finals of the Champions League. Pochettino talks about his years as a player and then a coach in this interview in The Times. He says nervousness as a coach never bothered him as he was always so absorbed by the game and the players, and it could be a bit genetic too.

He was not active as a coach for a year after his departure from Tottenham Hotspur. Today he is seen as an effortless manager, with a natural disposition for the sport and a developer of talent.

There is an emotional attachment because he was close to PSG. "We took the decision because of our heart, not because whether it was the right moment to arrive in Paris or not," he says. "Now after 3 months we leave a very, very tough period."

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A 41 year old doctor, Vasant Narasimhan, is the new CEO of Novartis in Feb. 2018. Under Narasimhan R&D is expected to get prominence. His predecesor Mr. Jimenez's focus was on developing new prescription drugs. Dr. Narasimhan sees a shift to new technology, improving data science and digital capabilities to discover new medicines. This shift raises the possibility of a spinoff of the Alcon eyecare business and the Sandoz generics business.   Narasimhan joined Novartis in 2005 from consultancy Mckinsey & Co. and becoming head of R&D. He is expected to push a series of tech based initiatives including artificial intelligence to be used for new biomarkers showing effectiveness of treatment, new sensor technologies developed with Microsoft. This shift is a result of the earlier effort under previous CEO's to make up for the loss of patent protection on profitable drugs by diversifying into consumer healthcare. During the period under Jimenez Novartis share price performance was mediocre, rising 41% over 8 years. Its business is stagnant with a 1% increase in 2017 for revenues, the first increase in 3 years.   ...

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The situation for the day before the Iowa caucuses on Feb. 1, 2016, with voter turnout playing a key part in the election primary.

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Americans Harvey Alter, Charles Rice and Briton Michael Houghton win the Nobel Prize in Physiology and Medicine for the discovery of hepatitis C virus, which causes liver cancer. Before this discovery and the test for bloodborne virus giving blood transfusions was very risky as it could transmit Hepatitis C virus. Blood banks then used the test to make sure donors did not carry the virus. We now have millions of people benefit from safe blood transfusions and safe blood products. Drug makers then developed medicines for treating Hepatitis C virus. Dr. Alter worked at the U.S. National Institutes of Health in the 1970's and identified the unknown infectious agent that was not Hepatitis A or B virus. Dr. Houghton worked in the 1980's with pharma firm Chiron and isolated the genetic sequence of the then unknown virus. He now works at the University of Alberta in Canada. Dr. Rice, a researcher at Washington University in St. Louis found a component at the end of the Hepatitis C virus genome that played an important part in its ability to replicate. ...

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Both Ranbaxy and Dr.Reddy's, two of India's largest pharmaceutical companies, are bidding for Betapharm, Germany's fourth largest generic drugs maker. Ranbaxy's bid at 500 million euros was 50 million euros higher than Dr. Reddy's. Betapharm based in Augsburg, Germany, has sales of 161 million euros, and a workforce of 350. For Dr. Reddy's this is a way to get a foothold in a branded generic market in a developed country, says Dr. Reddy. This will be the largest foreign acquisition for an Indian pharmaceutical company.

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A report by pharmacy benefits managing company Express Scripts shows a 13% increase in the price of branded drugs in the U.S. from Sept 2011 to Sept 2012. Generic drug prices declined by 22% in this period. The report also shows that growing spending on specialty drugs for cancer, MS and other diseases is a big reason for the increase in prices of branded drugs. This report is from a random sample of six millon Express Scripts members using prescription drug coverage. Prof. Schondelmeyer of the University of Minnesota, who manages the drug benefits program at the university and conducts a similiar price report for AARP, says the potential benefits for these specialty drugs are not that good to justify the high prices.

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The 10 year distribution contract between Walgreen Co., Alliance Boots, and AmericsourceBergen Corp., for distribution of generic and other drugs worldwide. The higher volumes as a result of the distribution contract gives it leverage in negotiating better prices from generic manufacturers.

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The way a number of lawsuits and a antitrust investigation turn out about whether Abbott violated antitrust laws in efforts to prevent an Israeli company selling a generic version of Aboots drug for cholesterol called Tricor, will say a lot about how far drug companies can go in fighting generic versions coming from competitors.