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Thanks go to Pfizer and CEO Albert Bourla for their latest effort the antiviral pill Paxlovid, says the editorial Board of the WSJ. It reduces viral load ten fold and is a game changer in the pandemic, says the WSJ, when vaccinations are not as effective as they could be with the large number of unvaccinated. Pfizer charges $530 per treatment for the 10 million doses ordered by the Biden Administration and signed a voluntary licensing agreement with UN backed Medicines Patent Pool for worldwide access. This should enable access in all countries.

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European Medicines Agency approves the Pfizer BioNTech vaccine on December 21, 2020.

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Pfizer marketing of Lipitor for off label use.

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Two health service workers at NHS Britain experienced symptoms after receiving the Pfizer vaccine. NHS is told by medicines regulator that people with a history of significant allergic reactions should not be given the Pfizer vaccine.

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This NYT editorial says the Pfizer bid to acquire Astra Zeneca is an inversion, a tax maneouvre using openings in U.S. and British tax laws that allows an American company to incorporate in London by acquiring a British company. In effect Pfizer beomes a subsidiary of the British company. This reduces taxes owed even though business takes place at Pfizer as before. NYT says 25 companies have adopted inversions since 2008. The top corporate tax rate in Britain at 20% is lower thant the top rate of 35% in the U.S. Additional tax maoeuvres could make it easier for income shifting to tax havens, and make it possible to free up cash held in foreign countries without the need to first repatriate it to the U.S. The problem is that such maneouvres are taking place at a time of large U.S. deficits, and deep cuts in public services and government investment in R&D, infrastructure, education, that would lead to future economic growth.

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The experience of J&J and Novavax in vaccine manufacturing shows the importance of vaccine manufacturing and of Quality Assurance in the production of vaccines for coronavirus. The success of Pfizer and Indian companies in vaccine manufacturing shows how important it is to think early and plan early for vaccine manufacturing technologies, personnel and quality assurance. This is also why the US effort, India's billion vaccine target in 6-12 months of planning, is a great effort in thinking ahead of every aspect of vaccines and vaccinating, planning of all details, hard work, by Pfizer, by Indian pharmaceutical companies, and by the Modi and Biden administrations. 

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Pfizer cancels inhaled insulin drug Exubera, taking a huge charge of $2.8 billion .

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A strong immune response for BA.4 and BA.5 using Pfizer's second booster shot designed to tackle the new Omicron variants.

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India reports over 300,000 cases for the fourth day in a row. German chancellor Merkel passes legislation that gives the federal government the power to set curfews to control the spread of coronavirus. Cases reach 166 per 100,000 in Germany and the government sees lockdowns to be in place till the end of May. Streets in Dusseldorf and other German cities are shown deserted at night.  The European Union deal signed with Pfizer for 1.8 billion doses including booster doses of the Pfizer vaccine, provides new hope for the vigorous vaccination drive needed in Germany and the rest of Europe. 

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Moderna, J&J, Pfizer in the U.S., Sanofi in France, AstraZeneca in Britain, have accelerated their efforts to have a vaccine ready by the fall.  Moderna and Pfizer use new technologies. Astra Zeneca is working with Oxford University on a vaccine that builds on existing technologies. Both AstraZeneca and Sanofi are building capacity to make hundreds of millions of doses of the vaccine. 

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Pfizer's Jarvik campaign for Lipitor cost $258 million and is now cancelled after misleading claims and representing Jarvik as a credible spokesperson for Lipitor when he is neither a cardiologist or an inventor of the artificial heart. Another missstep by Pfizer.

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The failure of mega deals like the purchase of Warner Lambert and Pharmacia by Pfizer for $178 billion to do much in the long run. Pfizer's share price has fallen 70% in a decade and its market capitalization is $95 billion. J&J and Abbott have made smaller acquisitions and J&J's acquisitions have generated stable revenues with branded health-care products.

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The European Union has deals for 300 million doses of vaccine from BioNTech and Pfizer to be delivered soon. Germany is setting up hundreds of vaccination centers for first 3 months of 2021. Transport logistics are a concern. The Pfizer vaccine has to be kept at minus 70 degrees Celsius or minus 94 degrees Fahrenheit. Paul Ehrlich Institute is responsible for release of vaccine batches in Germany for rollout.  Good planning is essential for the huge task ahead.

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The reasons Exubera was conceived by Pfizer, the events leading to the persistance with backing Exubera with large investments in manufacturing and marketing and buying out Sanofi's stake in the face of repeated setbacks, the difficulties posed by a insulin inhaler from the very beginning. Bulkiness the size of a flashlight this inhaler was embarrassing to use in public, it required regular lung exams because the FDA placed a warning on theproduct because only 10% of the product went where it was intended and 90% was inhaled into the lungs and who knows what that could do especially for asthmatics but also for others. It cost twice as much instead of $2 or 3 it cost $5 per day. And the 3 milligram packet had to be loaded into the inhaler which required instructions on how to use, one doctor saying it woul take an hour to educate a patient compared to 5 minutes for an insulin pen. Abbott and Lilly have insulin inhalers that they are bringing to market in 2009. Abbott's uses aerosol insulin instead of powder, Lilly's is the size of a cellphone. Will they work for customers? Pfizer attributed as key cause of the failure to the need for regular lung exams because of the regulator's warnings for insulin inhaled into the lungs. Are Lilly and Abbott taking this problem seriously?...

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Companies that have consistently ranked high in the managing across several criteria in WSJ/Drucker rankings include Microsoft, Pfizer, P&G, Apple, Accenture, HP Inc. Focus on innovation, employees, in addition to customers is important to these companies.