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The Stimson Center looks at the closing of an era of Conservative politics in Japan which ended in 2025 after the death of Shinzo Abe and the 2 year premiership of Kishida. Interview is conducted by the Stimson Center of a senior Japanese political figure with 30 years of experience in the Foreign Service, and the author of the only English language book on Shinzo Abe, reflecting the paucity of research on Japan. Shinzo Abe was premier for a short time in 2005-2006 and for a full term in 2012. He made changes to Japan's SDF, its partnership with India, Australia in the Quad, and his economic policy which increased women's participation in the economy. For the first time in post war Japan there was a new sensde of confidence under Abe and he is missed sorely in Japan today. Yet as this senior Japanese politician says, Japan has changed the way the US and Europe have changed, and nationalist politics are replacing old Conservative politics of the LDP. In a way also how the deindustrialization of US, Europe and Japan has also taken place discrediting that era. Takaichi Sanae is itself a representative of the new era, as she did not hesitate to say Japan would get involved if China attacked Taiwan. Her popularity is at 62% and she has called a snap election, as she came in to replace Shigeru Ishiba in October 2025 and was not directly elected PM. Yet in the long view this is also a misconception because neither the Stimson Center or the interview participants had a keen sense of who Abe really was and Abe's grasp of the history of the Kamakura period of Buddhist Japan and China, India, of the 12th century before the foreign invasions from the north. One of Shinzo Abe's biggest legacies is the relationship that was close to his heart, the relationship with India and prime minister Modi. This week chancellor Merz of the Federal Republic of Germany was at the kite festival with PM Modi in Ahmedabad and at the Sabarmati Ashram of Gandhiji. The same degree of warmth shown by the German leader and Modi reflecting Vivekananda's time in Germany, was seen long time back between Modi and Abe. The bullet train project Mumbai to Ahmedabad and the ones that follow across India are a testimony to the warmth shown by Abe for India, and his knowledge of history from the Buddhist period in India when by the 12th century in Japan in Dogen's time Tenjiku (India) was the sacred homeland of Buddhism. Today India has revived the Buddhist traditions and centers of Buddhism, the universities and research centers for Buddhism from that period in Indian history. Buddhism started in India near Nepal in what is now Bihar state at Sarnath and Kushinagar, and spread through China to Japan and Korea. The whole continent of Asia would reflect Buddhist ideals and ideas without the intervening period of Vedic culture in India and China's Mongolian and Manchurian northern invasions, and the periods of European colonialism. Today Buddhism and The Bhagavad Gita are itself strung like pearls on a string as the Gita itself says, part of the long spiritual traditions of three nations- India, China and Japan, and of the many others Vietnam and Korea. ("All these worlds have their rest in me as many pearls on a string." -Mascaro tr. of Bhagavad Gita, Penguin). As Asian nations and peoples come to their own inner selves, find their inmost self, this is the culture that really pervades all of Asia. ...

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The resilience of U.S. large cap value stocks was shown in 2000-2002 and 2008-2009, and offered investors greater protection, according to research by Mark Hulbert of Hulbert Financial Digest.

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Watching Joanna Stern of WSJ interview Sam Altman and Murali Murthi gives the impression that Altman was  moving too quickly and Murthi was saying the right things but lacked the experience and capacity to tackle AI's vast responsibilities. This also stems from the fact that what young Stanford and other tech graduates in their early thirties have done in the last 2 decades ends a chapter in America's tech history. AI is an entirely different technology which requires the involvement of major parts of America's whole technological and scientific community and its society, not just a few individuals. This is also the lesson from the pandemic for virus research where not just the Cambridge, Massachusetts community needed to be involved, but vast parts of America'a health and medicine scientific community and the American public. A million lives were lost in the pandemic in the US alone, and millions all over the world. It is a lesson that should never be forgotten- that technology can get out of control. ...

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Pew Research looks at Inequality as an issue. It also looks at whether people see that their children will be better off financially when they grow up. The Better off Financially is not the same as the inequality issue, on inequality issue progress can be inadequate but perceived differently among different income groups in industrialized nations to be inconclusive as in this recent Pew Research in 2024.  On whether children will be Better off financially there is a decisive result in Pew Research in 2024. With France and Canada at the top 81% and 78%,  Italy and UK at 79%, the US at 74%, Japan 77%, Australia 79%, Spain 75%. Almost across all the European Union countries and the US this is decisive, a clear unequivocal result. Both the Trump first term and the Biden first term felt effects of Covid pandemic.  Reviving Manufacturing in the US and  Europe is the only way, and with it infrastructure investment, to bring back a sense of optimism to the US and Europe. For this levelling the playing field and tariffs that do that selectively are the plan in the second term, getting industry to take up the challenge is the second goal in this decade to 2030.    ...

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The Indian prime minister launches India's health infrastructure plan for medical colleges, medical facilities down to the district level, research facilities, under the Ayushman Bharat Mission. The plan was launched in India's largest state Uttar Pradesh with a population of 250 million people. It is designed to strengthen India's health infrastructure to tackle this and future pandemics.

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Scientists at the University of California, San Francisco say that manufacturers of PFAS forever chemicals are using a strategy to discredit good research that detail risks from carcinogens. They says that these manufacturers suppress unfavorable research and distort public discourse. Former EPA researcher Dourson is shown here with a company that gets half its funding from chemical companies. He pushes for allowing many times the permissible level of carcinogens set by the EPA, and supports use of forever chemicals, in this report in the WSJ. President Trump appointed him head of the chemcial safety unit at EPA, but Doursen withdrew when there was bipartisan criticism of ties to industry. Critics say he uses biased science that looks at cherry picked data. His company is called Toxicology Excellence for Risk Assessment, which he founded after taking a buyout of $25,000 from EPA, according to WSJ.

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At a time when ideas are held with passionate conviction, Andy Kohut kept a remarkable self-discipline in phrasing his questions for polls so as to hear clearly what people were thinking. He followed and loved a robust debate and saw his job as presenting the facts. The Pew Research Center's credibility has been enhanced by Andy Kohut's leadership. He led the Gallup polling organization for many years before becoming founding director of the Pew Research Center. At a time when more than ever we need to hear what is on people's minds, and provide a glimpse of this that goes beyond the passion and political spin in the news story, the work of Kohut is sorely missed.

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Research in Motion's new CEO, Thorsten Heins, says he has revamped the leadership team and his focus will now be on execution. He says that when he joined the company in 2007 it operated more like a startup. Heins wants to see founder Lazaridis in more of a visionary role. Product cycle times will be shortened as the teams will be more focussed from now on, says Heins. Heins sees one key part of RIM's strategy being getting new phones into the hands of users. Most Blackberry users have older model phones and Heins says only 10-15% of users know about the Blackberry 7 phones.

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A scientist from the Robert Koch Institute in Germany will head a WHO team going to China to conduct research on the origins of the coronavirus.

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WSJ research shows that as the complexities of offshore drilling increased during the last 2 decades, the government moved in the other direction towards less regulation and self regulation of the industry. In retrospect, just as in the financial crisis, the deepwater drilling crisis also showed the need for careful regulation. The risks and complexities of the processes involved increased tremendously during two decades, ultimately leading to enormous failures.

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Research on the experience with online learning during the pandemic shows the importance of blended learning. Having a mentor or someone to help the student taking online classes considerably improves the learning process. Without this online learning does not do as well as regular classroom instruction by teachers.

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Research on the human genes by Novartis researcher Dr. Rappouli has helped develop a vaccine for Meningitis B. In a unique collaboration with Craig Venter, the scientist who decoded the human genome, Dr Rappouli, an Italian scientist working for Novartis unit, Chiron Corp., describes his research effort and results to Jeanne Whalen of the WSJ in 2007.

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Should inflation be set at 2% or 3-4%? This decision affects jobs and zero interest rates hurt what retirees earn on savings.  Krugman says Americans were better off during the period under presidents including Kennedy-LBJ, Reagan right up to 2008 when interest rates were between 5-8%, and inflation of 4% was considered to be acceptable. Consider that about 90% of American retirees have savings of less than $100,000, and 50% have no savings at all after two decades of near zero interest rates. Krugman points out that Fed 2% inflation targeting is a mistake because the research is wrong and inflation of 2% gets you to near zero interest rates a third of the time, not 5% of the time as US Fed research incorrectly shows. Financial crises such as 2009 from lack of regulation of financial institutions and laissez faire policy led to zero interest rates that hurt average Americans.

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2013 will be a crucial year for Windows mobile software, according to IDC. IDC analysts say developer support is critical and mobile platforms that fall below 50% in support from developers 'very interested' in developing apps for them are likely to see a gradual demise. IDC's quarterly surveys of more than 4800 mobile apps developers shows Windows 8 tablets having such support from 33% of developers and Windows phone 7 software having 21% support. Research in Motion (RIM) has a mere 9% support for Blackberry phones and 8% for the PlayBook tablet. The figures for Apple iPhone are 85% and iPad are 83%, followed by Android phone 76%, Android tablet 66%.

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Across the US a high percentage of people have seasonal allergies- over 25% in adults and 19% in children. A research institute at University of Utah found that higher temperatures from climate change leads to higher pollen counts. A warmer winter and warmer temperatures earlier than usual have worsened allergies in 2023.

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For the regions hardest hit by the coronavirus and its variants- the US, Brazil, India, Europe, Russia, China and Africa, the researchers and the frontline workers in South Africa are doing an incredible job. This report by Stephanie Nolan in the NYT shows the work of researchers at KRISPS advanced medical research center and the frontline workers in South Africa, who are making a difference. Shown are researchers and scientists at KwaZulu Natal Research Innovation and Sequencing Platform in Durban, South Africa on whom the world depends for stepping up the fight against the coronavirus- Dr Tulio de Oliveira, principal investigator of the national genetic monitoring network, and Saleem Abdul Karim, epidemiologist. On the frontline workers who visit patients homes to make sure immune compromised patients have access to their medications is Sizakele Mathe, community health worker. Stephanie Nolan has provided a much needed account of what work is being done on the frontlines to keep us all safe. ...

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Japan is staying ahead in vaccine development with 5 vaccines under development including 1 MrNA vaccine. Vaccine makers using Japanese research are Shionogi, Anges, Daiichi Sankyo, KM Biologics, ID Pharm. Shoionogi also announced in May that it is working on vaccine for variants of coronavirus. Japanese vaccines were recently sent to Taiwan.

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Novartis is taking a new approach to drug research and drug discovery. The old one which was popular in the drug industry was to go directly for blockbuster drugs for large numbers of users, with a long time in the research pipeline because the area of research was largely an unknown. This was costly and becoming less and less productive. Dan Vasella who heads Novartis, is taking a different approach which comes from his understanding of medical science as a physician, in an industry run by accountants, lawyers and business people. This is to go after wellknown molecular pathways identified by Dr Fishman at Harvard in his research, and do this by taking on problems in diseases that afflict small numbers of people. These drugs have some established medical science to work with, and the research work takes a shorter period. Once the drug proves its effectiveness in one illness, it is tested for other illnesses that afflict a large number of people but which shares some of the same underlying phenomena that cause the disease in the two situations. Dr Vasella stumbled on this approach after the development of the drug Gleevec by Novartis. Gleevec was originally approved for a rare blood cancer, but has now shown to be effective against six other dieases. Gleevec brought 3.7 billion in revenues in 2008 for Novartis. In 2002 Vasella made a bold move to discard the old drug development model. The basis of this approach was to go after new drugs that were desperately needed and where the genetics of the illness were well understood. Whereas pursuing rare dieases is considered foolhardy by most drug company leaders, Vasella's idea is to use the common genetic underlying arrangements for that drug to go after other diseases that would be good prospects for the now proven drug. The known genetics makes it possible to complete the research in a shorter time. In 2009 Novartis has 93 drug candidates in the pipeline, 40% more than 3 years ago and 80% of Novartis' drugs last year made it from early testing to late stage development. This was a 60% improvement over 2005. The new approach fits the current regulatory climate, with regulators concerned more about safety, and Medicare and Medicaid and other payor less willing to pay for treatment with modest benefits or with uncertain outcomes. The approach had to be executed in terms of organization and staffing. Vasella moved the R&D global research operation from Basel to Cambridge, Massachusetts, and spent $4 billion on the move. He recruited a renowed researcher and cardiologist at Harvard University, Dr Mark Fishman, who had done research on the genetic mutations in the cardiovascular systems, to run the center and set the new direction for global research. Fishman convinced Vasella that medical research should focus on a small number of molecular pathways- the complex suquences of interactions among chemicals, proteins, and larger cell structures in the body that are behind all illnesses. Says Fishman, there are 24,000 genes in the genome, but only a few dozen pathways conserved through evolution. Fishman's theory is that you find all the links in a pathway and then locate the signals that can turn the genes on or off to develop medicines for illnesses. Bercause disease after disease share a common pathway, the knowledge gathered can then be applied across that region with more accuracy and directly, to address a range of illnesses. Fishman's approach means marketing and sales no longer make the decisions. There is a new method for doing things. Fishman focusses on clinical data and insists that commercial analysis comes after sufficient clinical data. A major restructuring in 2007 led to shedding 1260 sales and marketing jobs, as clinical science now takes precedence and medically trained scientists take senior leadership positions. The new approach is being used for a drug developed for Muckle-Wells syndrome. Computer simulations are shortening the time to late stage trials. The drug has applications for Type 2 diabetes and severe arthritis. The whole process will take many years, as its a sea change for the industry and for Novartis, a fresh approach when the approach used by the pharmaceutical industry for so long is failing. An oral drug treatment for multiple sclerosis is being developed along these lines. Afinitor. approved by the FDA for kidney cancer in March shows potential in six other diseases, including lymphoma where Afintor shrank tumors by 50% in one third of the patients in a trial. ...

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Jeremy Carl is the nominee for Assistant Secretary of State for International Organization Affairs (including UN) in Feb. 2026. He is a research fellow of the Hoover Institution at Stanford University. His BA is from Yale where he was president of the student union, and his Masters is from the Kennedy School of Government at Harvard University.  From 2004-2005 he was a visiting fellow at the Energy and Resources Institute in New Delhi, India.This article says he has been critical of Jewish attitudes yet he comes from a Jewish family and is now a member of the Presbyterian church. He was Deputy Assistant Secretary of the Interior in the first term of DJT. His recent book is on the theme of how the culture and attitude of America was culture an attitude of vast majority of the population from 1600 till 1965 for about 400 years. The Immigration laws of 1965 under JFK/Johnson, he says were not intended to change this, yet a change and relaxation of tight immigration policy has led to the situation similar to what Eisenhower faced in 1954 that led to Operation Wetback- as Mexican immigration surged in the war years by the early 1950's. For 150 years before 1965 the US only opened up for Europeans immigrating to the US. The changes since 1965 coincided with deindustrializationn of the US and the failure of the governing class to do anything about the steady shipping out the nation's manufacturing sector to China. Which is why there is so much anxiety about America's position in the world and a sense of a culture that is being lost- of Robert Frost's poetry set in New Hampshire, of Shakespeare's plays and morals for Western civilization, of the values of Emerson and Thoreau that guided Gandhiji and other Asian leaders. ...

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This report in FR24 cites the director of research at France's National Institute of Health and Medical Research, Inserm, about the damaging effects of an insecticide used in the French West Indies. The result is that there are violent protests against the vaccine mandate being implemented in the French West Indies. 

The FR24 report says that about a third of the marine coastline, and a third of agricultural land and land for breeding, in the West Indies islands of Guadeloupe and Martinique is polluted by the insecticide chlordecone. The insecticide was first used in banana plantations in the French West Indies against banana insects. The insecticide has now contaminated the soil and groundwater. 

 

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Daniel Webster once said the Nation will do fine as long as it retained faith in the Bible and in spirituality. In 2025 33% of Americans attend religious services, 68% (Christians Jews Buddhist/Hindu) pray once a day, 80% believe in spirituality. This is shown in the Pew Research Religious Landscape Report just out in 2025. In America 40% are Protestant, 19% Catholic, 4% other Christian, and 2% Jewish, 2% Buddhist/Hindu. About 65% of the population openly identify with Christianity and the Bible, and this is now stabilized over the last 5 years. It is important to remember that Abraham Lincoln questioned some church religiosity and practices, yet had a profound belief in the Bible, his Devotional based on the Bible that was published in London in 1854 was one that he kept with him for most of the years serving the Nation. For close to 70% of the population having a belief in the Bible, and in God, is a good sign for the future of the Nation as it approaches it's 250th year, and a community that settled these British colonies and a vast continent since the 1600's for 400 years. ...

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This article in the NYT cites research published in JAMA that shows higher rates of depression among women who complete medical residency training, because of the larger share of child care and household duties. This places a bigger burden on women than their male counterparts, even though the long hours and strenuous duties create a high rate of depression for doctors.

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The 177 acre campus in Ann Arbor, Michigan, that is the Pfizer Research labs is closed, sealed off and silent, an empty place, now that Pfizer has decided to close the labs for good. Lipitor was invented here by a group of researchers who had their foundation in chemistry. One of them was a Yugoslavian immigrant to the UK who moved here, Dr Sliskovic to join Warner Lambert. Pfizer acquired Warner Lambert in 2000, now 7 years later the Labs are closed as chemist based research has not produced much in results.For years chemists at these labs have labored without finding a new drug. The success of Lipitor has sustained this research generating $13 billion a year. But now Pfizer is looking to outsource some of the chemist based work to places like India. Some of the research money will go to biotech research which now looks more promising and research will be handled from it Coonecticut based research offices. The whole field of chemistry based resarch for pharmaceuticals is changing and is not what it once was and chemists are looking for jobs in other fields....

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The Raleign area in North Carolina near the location of 3 research oriented universities is rebounding quickly from the pandemic. It is now No. 3 in WSJ's annual survey of US labor markets with big gains in wags and jobs. This report in WSJ looks at how this was done with business, communities and local government working together.

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Shares of Adani Enterprises went up by 3000% over 5 years putting valuations at extreme levels, says this report in the WSJ. This has created a disconnect between valuations and fundamentals say some experts. Hindenburg Research is a American forensic financial research firm started in 2017 by Nathan Anderson in New York City with 5 employees. It has issued a critical report of the Adani Group companies leading to a loss of 18.5% of its valuation. Adani Group companies make up 5% of the Bombay Stock Exchange and are a big part of its renewable energy effort even though the company had major interests in coal in Australia. Adani is trying to make the switch to renewable solar and wind energy and at the same time meet India's continuing need for coal because of its large population. The situation is similar to China and is poorly understood in the US and Europe, the effort to make large investments in renewable energy even as the company provides energy from fossil fuels. Adani set up the Mundra port in Gujarat helping Gujarat become energy sufficient and making it the most industrialized part of India. The London based Financial Times took a look at the Adani Group long before Hindenburg Research in the last 2 years and concluded that Adani Group companies have grown rapidly because India's effort for industrialization requires aggressive investment and risk taking which none of the other companies including India's Tata and Reliance Group are able to do in infrastructure and energy in the same way that Adani has. Reliance Group has invested in 4G and 5G and setup Jio to create low cost access to fast internet in India. When it comes to roads, airports, coal and renewable energy Adani has invested aggressively. This has created the perception that the Adani Group has benefited from its relations with the government. As the Financial Times put it Adani Group was the only private investor willing to take up the challenge of super sized goals needed for India's rapid growth. In this sense a forensic research company based on short selling is up against a company that has already faced skepticism about its rapid emergence as a renewable energy focused company shifting from fossil fuels, a transition neither Exxon or Chevron in the US have been able to do. ...