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The new head of Roche, Severin Schwan, sees a huge opportunity in the current state of pharmaceuticals. He says drugmaking is still "so crude," because half of all known diseases cannot be treated at all, and the drugs for the diseases that are being treated don't work as well as they should and with a lot of side effects that make serious drawbacks in using them. He compares this state of affairs to acar that starts only half of the time and has brakes that don't always work. What gets hime excited is the rapid advances in diagnostics, genomics and biotechnology that can bring a"brand new revolution" in personalized medicine. He is pushing forward in the areas of biotechnology with the $47 billion deal that integrates Genentech into Roche, and in molecular diagnostics with the integration of 454 Life Sciences and Ventana. Doubts were raised during the integration of Genentech into Roche about whether the research climate at Genentech could be preserved and whether research scinetists would leave. But most have stayed. With the resources of a larger company behind Genentech and the patient approach that a firm with a founding family controlling the firm can take under a leadership determined to invest in research, experts like Tim Anderson of Bernstein Research see Roche well positioned to grow by aquarter over the next five years....

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Very important interview with the Vice Chairman of Chevron, Peter Robertson. He gives a very thoughtful view of the answers to the most important questions about oil, what will the price be like, what will it depend on happening, are some of the numbers being put out for 2030 realistic, and what can materially change the scenarios. He is frank about not knowing how this will come out, who knows the production numbers some years from now, it depends on a number of things happening, Iraq, Iran, Venezuela, Mexico, Russia, can potentially increase production if they make the necessary investments. In the case of Iraq having a stable government and peaceful transition. What happens in efficiency will define the picture on the demand side as we are already seeing new fuel economy standards and conservation across the board in all uses of energy. Robertson sees a lower price, but over time as new production comes on stream and bottlenecks in investment such as shortage of technical resources pool are overcome, and at the same time as conservation really kicks in including fuel economy and other methods. He sees production of 125 million barrels per day as a stretch, a twice stretch as the 80 million barrels per day now produced will become a low number so that will have to be pulled up too to reach the 125 number....

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The House healthcare bill that just passed by amargin of 220 to 215. The cost would be $1.055 trillion over 10 years, with cost of $894 billion factoring in penalties for individuals and businesses that don't buy insurance. Adding increased coverage for Medicare prescirption drug coverage for seniors its around $1.2 trillion. $460 billion is from new taxes on single people with income of over $500,000 or couples with inocme of $1 million. There are $400 billion in cuts to Medicare and Medicaid, and additional money coming from penalties for not buying insurance. First column here is Senate version, second for House version and third President's version. Other features individuals must have insurance or pay afee of 2.5% of income, hardhip waivers will be available. Employers must provide insurance to employees or pay a penalty of 8% of payroll. Small businesses with fewer than 10 workers get tax credits. The threshhold is $500,000 of payroll. To help families with lower incomes and the poor the bill provides: families earning $29,000 a year pay no more than 1.5% of income for premiums. Families with incomes of $88,000 ayear would pay no more than 12% of income for premiums. ...

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Olivier Blanchard, chief economist of the IMF says that as government borrowing around the world surges, interest rates will go up. Governments borrow by selling bonds to investors, and to attract investors the government competes with stock and corporate bond markets for investor's money, leading to rising yields for investors. As the confidence has returned to corporate bond markets this is already happening. From the end of 2008. the yield on the benchmark 10 year Treasury note has increased by one and ahalf percentage points, rising to 3.54% from 2%, the sharpest upward movement in 15 years. In Germany the yield on German 10 year bonds has also risen, rising to 3.57% from 2.93%. Similiarly British bond yields have risen to 3.78% from 3.41%. Congressional Budget Office estimates are that net government debt for the USA will rise to 65% of GDP at the end of fiscal 2010, from 41% at the end of fiscal 2008. In 2009 and 2010 the US government will sell $5 trillion in new debt, according to Citigroup. A decade from now the government's outstanding debt could equal 82% of GDP, or about $17 trillion. Every one point rise in interest rates costs the Treasury $50 billion annually over a few years, and Kenneth Rogoff estimates that this could reach $170 billion annually if the average yield on 10 year Treasury note goes up to 4.7%, as the Congressional Budget Office estimates. This will dampen the effects of stimulus spending. It is a big issue says Rogoff. A year ago under old policy and assumptions before the financial crisis the Congressional Budget Office projected outstanding debt at $5.3 trillion in 10 years. Now the estimate is $17 trillion, which is triple the old number and an increase of $11 trillion. A recovering economy would make these numbers less relevant. But with struggling industries like autos and banks needing more help from the government, and with consumers having to reduce a mountain of debt, a weak economy for a long time and small growth for a decade would make this a story that won't go away. Rogoff says its like what happened to the subprime borrowers, people assuming that the funding is always going to be there. In 2009 and 2010 Citigroup says, the Euro zone countries will sell nearly 1.6 trillion euros or $2.6 trillion in new debt, and Britain will offer 490 billion pounds or $799 billion in new debt. Over the next decade this would slow Europe's recovery and prolong the downturn. Britain faces a bigger problem in the near term as Britain's governmetn debt equals 55% of GDP, and Standard and Poors estimates it could approach 100% by 2013. South America and Eastern Europe will also face the situation of rising rates. Asian countries like China with lower levels of debt are in a better situation, IMF's Blanchard says....

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In a aspirational country where even US president John Kennedy's grandparent's father Patrick Joseph arrived from Ireland during the potato famine in the 1850's and aspired to reaching the level of the more educated Americans over 2 generations, whose grandson JFK's father worked as a manager in the Quincy shipyards in Massachusetts, this extraordinary concentration of support for Republicans among less educated is astonishing, perplexing, and at odds with what America is. Super Tuesday results analysis of 1000 counties in 14 states in 2024 show Republican Trump getting 83% of the vote in counties with a higher share of voters without a college education. Where voters are a higher share of the college population this drops to 61%. A sharp drop in support is seen in counties with a higher percentage of voters who have college a rapid fall as one has college education.  A strange phenomena can be seen in graphs shown in WSJ of voters by counties and income, education. A large cluster of voters in incomes below 70,000 and without a college education then falling off like off a cliff. In Iowa, New Hampshire primaries it was seen as being mostly rural voters, more isolated and in less proximity to other people. The question remains how well this category of under $70,000 without a college degree reflects the country as a whole in 2024, how has the country changed since 2012, 2016 and 2020. It is easily said there is a polarized country yet this ignores the unusual nature of this support where it is concentrated so heavily in one group in this way with cutoff of $70,000 falling precipitiously in support for Trump for incomes above that. At above $70,000 support quickly drops to 80% and falls steeply with every $1000 increase in income after that. In a country like the US this means almost the entire educated population in the US and the entire population above the $70,000 per year level excluding itself from support, so sharp is the fall off from moderate income and education levels, and so heavily clustered is the support almost like a ball up in that corner of the graph with just a few specks on the rest of the graph. This is most unusual for the US and may not be reflective of the whole population of the US in 2024. This is also unprecedented in US history since 1776, may not compare to 2016, and for the Republican party even more unusual. Two questions also come up what happened to all the country club, more educated voters who voted Republican and made the party what it was an upper class business supported party, and what happened to all the factory workers, teachers, nurses and others in America who make about $70,000 or $80,000 and who are generally Democratic. These people will be part of the electorate for the whole country in 2024. ...

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Sweden gets a centre left government led by Stefan Lofven, who gets a second term in office. He managed to put together an alliance of centre left parties with the Green Party and Liberal paties after the elections gave 40% of the vote to centre left and centre right and proved inconclusive. Lofven governs without a majority in parliament because the minority government has support form other parties with 77 votes in parliament that abstained. Both centre right and centre left did not want to join with the far right anti-immigration Sweden Democrats. Lofven says Sweden chose a different path than other governments that sought to form governments with anti-immigrant parties. He said "in Sweden we stand up for democracy, for equality. Sweden has chosen a different path." To get Centre and Liberal parties support Lofven promised to cut taxes, reform the rental housing market, and relax strict employment laws.

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Fed chairman Bernanke's first news conference and Q&A. Efforts by the Fed to reach out and present its view of the economy to the American public.

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Nationally the new Omicron offshoot variant, the XBB.1.5 represents 40.5% of the cases in the US by Dec. 31, according to the Centers for Disease Prevention and Control or CDC. In New England and New York it is about 75% of cases and is a rapidly rising variant in Europe also. Only 38% of persons over 65 years in the US have got the updated covid booster bivalent vaccine shot.

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New rules enacted after the Reserve Primary Fund broke the buck in the 2008 financial crisis would help prevent another problem for money market funds. Money market funds must keep 30 percent of their holdings in securities that can be converted into cash in 7 days. Another factor mitigating the impact of U.S. money market funds holding about 50% of their assets in European bank debt, is the action taken by the money market funds to reduce their holdings of this debt and shorten maturities. According to S&P estimates of the 500 U.S. and European money market funds rated by S&P, 80% of European bank holdings is limited to 3 months or less, and 95% to 6 months or less. Vanguard's chief investment officer says the situation would have to be one of a very rapid decline, and not just Greece but also impacting Spain and Italy for these debt holdings to result in losses for U.S. money funds.

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The apartment vacancy rate declined to 5.2% in fourth quarter 2011 from 6.6% in 2010, and down from 5.6% in the third quarter, according to Reis. The vacancy rate went up to 8.5% in 2009. Data from Reis shows rents went up in 71 of 82 markets it tracks. For the U.S. rents went up by an average 0.4% in the 4th quarter, to $1064 a month, increasing from $1026 in 2009. Rent growth for 2011 was 2%. Factors helping demand for apartment rentals are the reluctance of buyers to invest in a home when prices are declining in an uncertain economy, and fears of another downturn. Factors holding price increases down in New York are the declining jobs inthe financial services industry and the already high levels of rental prices- reaching $2876 a month. Demand in San Francisco and San Jose was higher and prices were up over 5% in 2011, with better properties raising rents by 10%.

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Simon Nixon looks at the different scenarios for Greece as it faces snap elections on Jan. 25, 2015. He makes the point that unlike the situation in 2012 Greece's debt after considerable adjustment with creditors now looks sustainable. The nominal debt to GDP ratio remains high at over 170%, yet says Nixon, the long term average interest cost is about 2.3%. He even cites hedge fund Japonica Partners analysis showing Greece's debts valued on a discounted cash flow basis under international public accounting standards at a debt to GDP ratio of about 18%. Alexis Tsipras's left coalition if elected is likely to moderate its demands and continue with EU programs for Greece to restore confidence in financial markets and lower the interest rates on debt- including removal of special tax treatment exemptions and pension reforms. Support for EU membership remains high in Greece and Tsipras is likely to change his program to adapt just as Samaras and New Democracy Party did when it was elected....

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A detailed WSJ report by a number of reporters and journalists who were in the field during the hours and days when the fighting started. It shows that both sides had been preparing for a number of years for the fighting, the Russians in Abhkazia and South Ossetia and the Georgians, and the Russians and the Americans had supplied Georgia with new weapons so the US also was aware of the buildup. Its just that when the fighting started with shelling by both sides, and when Sashkavili made the decision to go into the S. Ossetian capital Tshkinvali he did not expect the Russians to respond so strongly, and Putin personally to respond the way he did. He totally misjudged Putin and the Russians. But the military preparations on both sides show that all sides were preparing for conflict and should the US have paid more attention to the region so that it was caught unawares.

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African Americans from Chicago, Harvard Law School and other places in Obama's background, some of whom came into government with the Clinton administration are likely to assume leadership positions.John Rogers of Ariel Capital Management, Valerie Jarrett, are from Chicago. Some of them are at law firms like Jeh Johnson who is a fellow partner of Theodore Sorensen speechwriter for President Kennedy. These are a new group of younger African Americans different from the earlier generation of Andy Young and Vernon Johnson. Eric Holder was deputy attorney general under Clinton, now his name is mentioned for Attorney General. Ties in Chicago include ties to Martin Nesbitt, a close friend, who is chairman of the Chicago Housing Authority and a real estate developer. Harvard Law School admits 30 to 40 black students each year, and it has 1400 black law school alumni, more blacck law school graduates than any other school except Howard University. And its a source for fundraising and other contacts....

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A critical point mentioned is that for a heavy polluter like China, the slowdown means less production of heavy industry like cement and steel that produces few jobs and has large emissions. The slowdown is an opportunity to make a transition to a greener economy that creates more jobs. The spokesperson for the European Commission says it depends on the vision and foresight of European, American and Chinese leadership whether they use the transition as a short term bitter apple to create new sectors that help in conservation, the environment, and for jobs, all at the same time. Government incentives and mandates, education, and leadership may be critical to doing this. Business and the private sector and markets can be shortsighted in this respect, and lack the will and staying power to see it through, leading to suboptimal results at best or destructive results as critical time is lost in indecision or inaction.

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UK's Keir Starmer makes 6 pledges to the British people- "Living standards should rise so that growth was felt by everyone, everywhere." Real household disposable income per person, GDP per capita by 2029. Build 1.5 million new homes in 5 years and fast track 150 planning decisions on major infrastructure projects. 92% of patients have to wait no more than 18 weeks for routine operations and appointments by March 2029. 29,000 officers for neighborhood policing and stopping anti-social behavior-1 for every 8000 people. 95% of low carbon electricity generation by 2030. 5% gas generation kept in reserve for unanticipated situations. It is Boris Johnson's target from 2022 in contrast to DJT's reverting to oil and gas to 2027 with industry following its continued but slower shift to gas and wind/solar. A pledge on living standards as the goal not growth is what Starmer sees as the dire need today. Growth that would put the UK ahead of all countries in the G7 is put aside for raising living standards for ALL the British people. A recognition that the two can mean very different things. Under the current plan fufilfillment of pledges is seen in the growth rate of 0.5% a year that is set in 2024. ...

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Sales of autos once at 14 to 24% increase year after year was down to essentially flat in the latter part of the year with full year growth at about 6.7% over 2007. And 2009 could be flat or see declines in sales. Consumers are feeling the effects f drop in the stock market and drop in housing prices as well as a slowing economy.

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Ian Thompson takes over as the new Chief Credit Officer at S&P. He replaces Mark Adelson, who will remain as a senior fellow at S&P. He was hired by the previous CEO, Deven Sharma. Deven Sarma was replaced by former Citigroup excutive, Doug Peterson, in September 2011, weeks after the downgrading of the U.S. sovereign credit rating. Ian Thompson reported to Mr. Adelson, as the head of the Asia-Pacific region. Adelson joined in 2008 with the task of making it difficult to earn the highest credit rating for issuers following the subprime mortgage crisis, in which credit rating firms gave top ratings to lower quality mortgage securities. Mr. Jacob, the structured finance chief, will also be leaving S&P. The frequent management changes are viewed as making it harder for S&P to win back credibility in its ratings.

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The lack of demand for Italian bank Unicredit's rights offering. The European Banking Authority is requiring European banks to increase their core Tier 1 capital ratios to 9%, to improve the cushion against a financial crisis. Unicredit will have to raise its reserves by $10 billion. Unicredit's shares have fallen sharply in January, with a decline of over 40%. Spain's Santander which has operations in Latin America was able to raise the $19 billion it needed for the higher capital reserves. Santander converted $6.8 billion euros in bonds into shares, retained profits and sold a stake in its Brazilian operations. The risk is that Unicredit and other European banks might cut lending to meet the new capital standards, leading to credit tightening and reducing economic growth further, says Carl Weinberg, chief economist of High Frequency Economics.

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Total's new CEO, Patrick Pouyanne, is moving ahead with plans for the $27 billion Russian Arctic Yamal LNG project. As China shifts away from coal with increased imports of LNG and pipeline natural gas, it is keen on providing financing for the project. Chinese banks will provide the bulk of the financing. Pouyanne disclosed in an WSJ interview that this would be $15 billion in Chinese bank financing to be arranged in 2015. Most of the LNG will go to meet China's needs. Partners in the Yamal project are OAO Novatek of Russia, and China National Petroleum Corporation. OAO Novatek's major shareholder is on the western sanctions list making it difficult to obtain financing from western banks. This makes the project riskier because of foreign exchange risks taken on by Total SA which are to hedge against.

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Casey points to the co-dependency between stock market investors in the U.S. and the Bernanke Federal Reserve. The stock market slumped in July 2013 and then hit new highs when Fed chairman Bernanke clarified that monetary policy will contiue to be accomodative for a long period with rates low even as the Fed tapers off its bond purchases. This makes the task of normalizing interest rates tricky for the Fed. Bernanke and the rest of the Open Market Committee have to consider the problems of a bubble in the stock markets, avoiding a destabilizing selloff in markets because of strong signals of normalization of rates, and changes in economic conditions in the U.S. and to some exent globally. Similiar reassuring statements were made by the head of the Bank of Japan, Bank of England and the ECB.

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Note the shift to internet based access and use of software. this is happening already in information access, which Google does over the internet. When it comes to applications we see the traditional model of installed software for Microsoft and Oracle. So there is a gap for someone larger and with the resources to make it work to come into this gap and use it to get a lead over its competitors. This maybe what SAP is about to do. The pricing of the software is at $149 oer user per month and the target is to increase customers to 100,000 by 2010 double its present customer base. The project is called Business ByDesign and 12,300 out of 61,000 developers at SAp are working on this new software. About $560 million will go into marketing and getting it off the ground to users.