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Americans Harvey Alter, Charles Rice and Briton Michael Houghton win the Nobel Prize in Physiology and Medicine for the discovery of hepatitis C virus, which causes liver cancer. Before this discovery and the test for bloodborne virus giving blood transfusions was very risky as it could transmit Hepatitis C virus. Blood banks then used the test to make sure donors did not carry the virus. We now have millions of people benefit from safe blood transfusions and safe blood products. Drug makers then developed medicines for treating Hepatitis C virus. Dr. Alter worked at the U.S. National Institutes of Health in the 1970's and identified the unknown infectious agent that was not Hepatitis A or B virus. Dr. Houghton worked in the 1980's with pharma firm Chiron and isolated the genetic sequence of the then unknown virus. He now works at the University of Alberta in Canada. Dr. Rice, a researcher at Washington University in St. Louis found a component at the end of the Hepatitis C virus genome that played an important part in its ability to replicate. ...

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Credit card balances of Brazilians increased by 29% in 2009, of Chinese by 17%, according to the Lafferty Group.

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Consider different budgeting styles depending on your habits and attitudes. It could fit in somewere between a definite budget and no budget approach. The important thing in keeping a check on spending is to have the approach that helps you with behaviours that pull you in the direction of action, reflection, self-discovery, say experts. 

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The Voyage of the Beagle is full of Darwin's youthful prose and is an exciting read. But what of the places he had been to like the Galapagos islands and St Helena. They are not the same as Darwin found them and will never be the unspoiled nature that he saw.

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Curiosity had a lot to do with the Renaissance in Europe, the Voyages of Discovery from 1500 to 1800, with the Discoveries in Science in Europe since the 16th century, and the Industrial Revolution in Europe.  Curiosity sets out a new way of thinking. This helped Europe to surpass Asia after the Renaissance. The Voyages of Discovery were motivated by an effort to fill gaps in knowledge about the world beyond one's shores in the Atlantic, and other oceans. Jamie Jirout of the University of Virginia shows how this works- The qualities needed are Interest, Creativity, Open Mindedness, Intellectual Humility, Intellectual Courage, Critical Thinking. This leads to internal curiosity and mental frame to be Intrinsically motivated to seek information, Identify knowledge gaps to think in new or different ways, be Open to things Unknown, Comfortable with risks of failure or mistakes, Challenge and change one's own thinking. This manifests itself in Behaviours that Explore and seek new information, Try things in new ways, Observation, Asking Questions and persisting after failure, questioning things verbally.         ...

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A old $2 million coal mine in Wyoming is now the biggest find for rare earth elements in the US since 1952. It could be worth as much as $37 billion says this report in WSJ. Randall Watkins the son of Ashland Oil founder the elder Watkins, runs Ramaco, the $600 million metallurgical coal company that bought this coal mine. He says he has learned lessons from his father that will help him build on this rare earth elements discovery for commercialization.

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A Spanish engineer tries keeping a log of all activities during the day to discover where time is going and slow the passing of time. This enable a better redirection of time such as walking to work, and improvements that add up over time.

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The cooperation announced between India and Britain on the experiment to look at one grid between countries in different time zones could be a game changer in the way new technologies have already achieved in making solar less costly than fossil fuel. Embrace of new technologies is essential for achieving net zero emissions. India first proposed connecting solar energy across countries and time zones at the International Solar Alliance in 2018. If a way can be found to integrate the grid across time zones the problems of solar energy could be tackled effectively. Storage would not be needed in the way it is now as the solar energy can be sent to other areas with the demand. And the equally vexing problem of supply can be solved as the regions such as Spain could be generating solar energy when the sun had set in India. It is ambitious but it also brings in scientists and engineers from Europe, America, India and Japan to tackle the problem. There is also the opportunity to build on one discovery to make another scientific discovery in the way advances have happened in medicine and science.  And nothing about net zero is not ambitious. One of the lessons Modi learned early in Gujarat is that experiments are needed and to never rule out new ideas. In some of his speeches he describes the early experiments with electricity and solar energy in Gujarat that led to more ambitious efforts over time, and eventually to where solar targets like the one made at COP26 Glasgow of 500 gigawatts by 2030 are now within reach. ...

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How Honda will act to meet a slowdown in the US market.

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Will AI reduce the curiosity that drives the creation of new knowledge and the curiosity for new discoveries that powered science and technology since 1600? Will it affect the human tendency and habit of asking questions, seeking out novel answers that is intrinsically human that AI cannot do? Scientific inventions that led to Europe leading the way and Asia falling behind after 1600 and new inventions taking place for 300 years with old theories discarded and new knowledge created are impossible under an AI arrangement. If AI existed in 1600 few new discoveries would have happened because they involve asking new questions and finding answers to these questions that take many years sometimes a lifetime of discovery and invention. Other weaknesses of AI are for example that it is fast but it cannot think- it is pieces of knowledge pinned together in different ways that come up from billions of pieces of information pieced together. It gives the appearance of thinking if one is not careful to look at it's process diligently. Its main source is using the public knowledge base built by Wikipedia, with other additions piled on top. Wikipedia may be wrong there are biases and tendencies to overlook facts in Wikipedia inherent in any knowledge exercise. These are then transferred to AI without anyone knowing about it openly, making it more dangerous in that it precludes creative thinking and finding solutions that never existed before to problems or questions, which can only be done by the human mind through its curiosity and stubborn dogged desire to find solutions to a problem.  ...

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Dr Kevin Lee, a British neuroscientist, heads EpiNova, a 60 person unit within Glaxo's R&D department. Lee founded two biotech startups before joining Glaxo. The smaller units called Discovery Performance Units are Glaxo's way of creating biotech startup like units which it is hoped will produce better results. The 36 DPU's in Glaxo R&D are given 3 year budgets and flexibility to make their own decisions for drug research. The large bureaucracy, scientists not working across fields and an older mindset are seen as obstacles in the search for new drugs. EpiNova with its own logo operates in a a Glaxo facility, an hour north of London. Decisions are made faster, says EpiNova chemist Dr. Wilson, and the atmosphere is that of a startup willing to try new approaches quickly.

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Indian companies and the speed and effective ways they do research offers a new model for western pharmaceutical companies and many of them are collaborating and setting up partnerships to discover and benefit from new drugs.

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Five biking and hiking Trails that take you to- Vermont across Lake Champlain on the 3 mile Colchester Causeway that runs across the lake.

Colorado between Aspen and Glenwood Springs for 18 miles that takes you around Dillon Reservoir.

Austin, Texas right near the city on the Butler Hike and Bike Trail to Northshore Overlook. The long narrow reservoir is a dammed up section of the Colorado River.

Sacramento, California, go across the Sacramento River on the Sundial Bridge, all the way to Redding. Views of Trinity Alps to the west.

Around Seattle, take the Olympic Discovery Trail that stretches along the coast, and coastal wetland, fir tree forests, for 135 miles from Port Angeles. Near a US coast Guard Base past Edith Hook for a view of the Olympic Mountains.

 

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Since the ouster of Mr. Licht amid falling ratings at CNN and protests by staff, the network is run by Amy Entelis, Virginia Moseley, Eric Shearling and David Leavy reporting to Mr. Zaslav head of Warner Brothers Discovery. CNN will now be run by Mark Thompson who ran BBC and New York Times. It comes at an important time for the country as 2024 is an election year. Mr. Licht was a late show producer, Mr. Thompson brings rare and extensive experience running large organizations that cover news for many decades since joining BBC in 1979. He joined as a BBC trainee and over 24 years by 2004 he headed the  vast BBC British network. 

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Bidenomics and how it works for America- you don't have to have a college degree and two thirds of the workforce doesn't have one, you don't have to move and most people can't move to costly housing locations like California or New York. America can build here at home in chips, aviation and advanced technologies in scale and discovery that it has in its heritage. And you don't have to move when factories can go up in all parts of America, rural areas, small towns, and in neglected factory towns from a different era of the 50's and 60's. This is what Biden is doing with trillions of dollars in spending with the help of some Republicans sharing his vision for American Renewal. Not just talk- just substance, results. And cost of living- inflation cut in half from 2022 to 4%.

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One of the great achievements of this century will go unreported in the media preoccupied with other things- the discovery of the Covid Pfizer vaccine by Turici and Sahin Turkish immigrants to Germany and their extraordinary courage recognized by being awarded Germany's National Prize by chancellor Merz. Germany's National Prize awarded to Ozlem Tureci and Ugur Sahin for BioNTech Covid Vaccine.  "You both embody the future strength of a liberal society. As scientists who seek solutions. But also as entrepreneurs for whom responsibility is at the center of their work." Merz says during the award ceremony in Berlin. The chancellor praised Türeci and Sahin, with their Turkish roots, giving examples of how "skilled labor immigration can be a driver of progress." "I want to live in a Germany in which talent is promoted to the best of our ability, regardless of social or ethnic background." ...

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What is the point of winning the World Cup says Steve Thompson, 2003 Rugby World Cup player for England, if you have to deal with the rubbish that comes after it. At 42 he can't remember his wife's name.  He has been diagnosed with dementia. It appears that all the knocks to the head taken in the game have affected his memory. This report in The Times looks at the reality and anguish of sports players who discover years later what happened during the time they played.

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This report by Jia Lynn Yang in NYT covers only the Coolidge period and the JFK period ignoring the wider trend since the 1850's when immigration from Asia to the US was discouraged. The laws limiting Japanese, Chinese and Indian immigrants were put in place long before 1924 by the 1890's. Japan agreed to limit immigration to the US under an agreement with the US after 1900. China was undergoing a transition under the Boxer Rebellion and upheaval in government in the period after 1900, India was part of Britain's colonial Empire.It does not mention that Chinese laborers helped do the dangerous work to build the railroads east to west. It also ignores the immigration from Mexico which was a special case in immigration because of Mexico's relationship along the border, first with the Mexican American War that achieved Jefferson's idea of a continental nation coast to coast. Mexico was a source of labor for US agriculture in the 1930's and 1940's when Asian immigration was severely constrained. When Gen. Eisenhower won the election in 1952 immigration policy was on the agenda, in fact Truman had a commission look at it by 1950. Operation Wetback was launched by Eisenhower and returned millions of Mexican migrants back to Mexico. Fearing the lack of farm help for Mexican agriculture Mexican agricultural interests supported the return of migrants. All this is left out by Lynn Yang. For almost a century Asian immigration was discouraged till JFK with experience in Asia during the war looked at Asian immigration to US differently passing new legislation to support this in the JFK/LBJ terms as president. In this sense the operations under DJT at the Border  and in the US in 2025-2026 are similar to what happened under Operation Wetback under a popular president Eisenhower, after the surge in Mexican migration adding millions of migrants to the US population in the 1930's and 1940's. A greater glimpse of the US can only be imagined if after the early immigration and discovery of the continent by the Spanish, the French and the British by 1600, the continent had not been unified first by the war of 1756-1763 with the French and Indian Wars creating the original 13 British colonies before the War of Independence in 1776, and the expansion to Spanish/Mexican territory to the West and South including California, Texas and Florida in the Mexican American War of 1846-48. In that situation there would be five sectors in America- British, Spanish, French, Mexican and American. The US could not have advanced as an industrial power divided in this way and would not have attracted immigrants from Europe the away it did. If it was split into two Southern confederacy and Northern Union states it would also have led to a similar situation. There would be conflict. It is only divine intervention and the courage and ideas of Jefferson and Washington, the work of president Polk, the leadership of Lincoln, and the industrial revolution on a large scale of one Nation in peace for most of the 19th century, that it became a haven for immigrants from a troubled Europe, a struggling Asia and Mexico. ...