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George Rathmann, is the scientist at Amgen who pushed for development of EPO, a hormone which stimulates red blood cell production, when the bio-tech venture company was struggling in the mid-1980's. After approval by the EPA in 1989, Epogen became Amgen's main product with sales of $2 billion in 2011. Rathmann graduated from Northwestern University, and received his PhD. from Princeton University in physical chemistry. He helped develop Scotchguard at 3M, and later headed the R&D department at the diagnostics division of Abbott Laboratories. He built Amgen from a staff of four in the early days in 1980, and it was his intuitive sense that Amgen should focus its entire effort on EPO development in the mid-1980's that led to its success.

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The problems in Chase bank's Investment Office unit were first reported in the WSJ April 5, 2012. Large positions were taken by Mr Michael Iksil, a trader in the London office that ruffled credit markets. Iksil reports to Achilles Macris, head of the European operations of the Investment Office unit, and Macris reports to Ms. Drew. At the time CEO Dimon and other executives reviewed trading positions and made no changes in strategies. After April 13 earnings call losses increased to $200 million a day, and review teams assigned to look into this found errors in the way the hedges were conducted. In early May Chief Risk Officer John Hogan and Europe head Daniel Pinto monitored the situation. The hedges were designed to reduce risk in the eurozone financial crisis, but the complex transactions based on relationships between a number of derivative indexes for investment grade and junk grade corporate bonds in U.S. and Europe worked in ways that led to large losses, and were so complicated that they were poorly understood....

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This editorial in WSJ says the lesson for Airbus after failed bids to get U.S. government contracts was that public perception about EADS Airbus as a European manufacturer affected its prospects. The selection of Alabama for the $600 million plant shows the attractions of that state as a right-to-work state that offered the right incentives, not just for Airbus but also for Mercedes and Toyota which have manufacturing plants in the state.

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Calpers, the largest pension fund in the U.S. representing 1.6 million California public employees, plans to liquidate $4 billion of investments in 30 hedge funds. Calpers sees the hedge funds as too costly with fees of about 2% of investments and 20% of profit, and too complex, lacking the ability to scale up for a pension fund of its size. Hedge funds have done poorly in the current investment environment where index funds have performed well.

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Shell plans to cut $15 billion in capital spending over 3 years, and pull back on shale investments, in response to the drop in oil prices below $50 a barrel in 2015. Shell's CEO Van Beurden says the company will continue to focus on capital efficiency and project delivery and make prudent investments. Since taking over Van Beurden has pulled back from big spending, cut costs, and focussed on capital efficiency.

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Zappos gets rid of job postings, saying they are a conversation killer, preventing a two way conversation with young people who are interested and fascinated with the company's unique way of doing business. Instead people who send out hundreds of resumes get to crowd out those who want to really engage in a relationship with the company. The answer is Zappos Insider which offers special membership for people who want to learn more about Zappos and its unique culture. Zappos ambassadors will act as people who carry the conversation forward with those who are interested.

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Intel's CEO is reversing his position that Intel Corp. will not operate as a general purpose fabrication facility. This is intended to keep operating its new chip fabricating facilities at full capacity by manufacturing other companies chip designs. As PC sales decline each quarter this is part of the new strategy.

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Ford's new 2013 Fusion model was radically redesigned to compete with the redesigned midsize Camry, and expected redesigns of the Honda Accord, Nissan Altima, the VW Passat and the Chevy Malibu. Ford hopes to gain market share with the Fusion after making only a small gain in market share of one tenth of a point in 2011, compared to half a percentage point for GM and 1.3 percentage points for Chrysler. VW Passat sales doubled in the last quarter of 2011 compared to all of 2010, showing increased competition in this segment. The new Fusion was designed at Ford's design center in Cologne, Germany, where the Focus was designed. Ford is shifting responsibility for car design to Europe and keeping pickup truck and SUV design in the U.S.

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Global infrastructure needs are expected to go up by 20% to 2.1 trillion dollars annually for the next 10 years compared to the previous ten years, according to the Samsung Economic Research Institute. India's investment in infrastructure will double to 1 trillion dollars in 2012-2017. compared to the prior five year period. Toshiba hopes to increase sales by 20% to $38 billion for nuclear power generation and distribution equipment and railway equipment, by the year ending March 2013. This is 38% of total revenue for Toshiba. Hitachi has set a goal of a 46% increase in sales to $29 billion, or 20% of total revenue for Jan 2011- March 2016. The Japanese Government and a consortium of Japanese companies are working together on deals such as the deal signed with Vietnam in October 2010 for nuclear power. The International Nuclear Energy Development of Japan entity, includes 12 companies and the Japanese government. The consortium was critical to negotiating the Vietnam deal.

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The S&P 500 has changed since 1998 for top 10 companies. Phillip Morris and Coca Cola are gone from the top 10. Apple at 256th is now the biggest by far exceeding Exxon by $200 billion in market value. J&J, Chevron are in, General Electric and Microsoft stay in. Added are Google and Wal-Mart in the top 10. Better management and vision played a role.