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German drug company Boehringer has applied for FDA approval for a drug that treats low female sexual drive for premenopausal women. A staff report by the FDA recommends not approving the drug. An FDA advisory panel meets this week to vote on whether the FDA should approve it. Meanwhile Boehringer is setting up a marketing campaign for the drug, including a website, Twitter feed, Discovery Channel documentary and a publicity tour by Lis Rinna, a soap opera actress. Boehringer's R&D designed the drug to treat depression but it did not work. Along the way Boehringer discovered that this drug, flibanserin, taken for weeks restores female sexual drive. It works by reducing the brain chemical serotonin and increasing dopamine. Results for this drug in a medical conference report show that the increased self-reported "sexually satisfing events" to 4.5 a month on average, and this compares to 3.7 a month on a placebo, and 2.7 for women not taking any pill. Critics at Georgetown University say this shows how drug companies are medicalizing normal conditions, and working on the insecurities and psychology of people. ...

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Standard & Poors downgraded the U.S. credit rating from AAA to AA+. In its reasons for the downgrade the ratings agency said the "political brinksmanship" in debt ceiling and deficit reduction negotiations has made the process "less stable, less effective and less predictable." It said the $2.1 trillion savings under the August 2 Debt legislation falls short of what is needed to improve U.S. finances. David Beers, the head of the government debt ratings unit at S&P also said that "we don't think it's coming back any time soon." Countries that still have a AAA rating are Canada, France, Germany, and Britain. Countries with AA+ rating include New Zealand and Belgium.

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Safety lapses at Southwest show that a Southwest maintenance person and an FAA officer at the local FAA office were involved in failure to conduct certain timely inspections on 46 older model aircraft. The local FAA office allowed Southwest to continue making 1400 flights while the safety structural inspections were being made contrarty to FAA rules.

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Rugged hilly coast and shallow narrow straits - problems for Straits of Hormuz shipping is shown in the NYT following similar reports in WSJ. It will cost $200 billion for the munitions supplies and interceptors, and US naval operations, French naval operations to keep the Straits of Hormuz open, which is supported by US business as is seen in opinion in Editorial Board of WSJ on March 24, 2026. The Straits are a lifeline for Asia until renewable energy and alternative supplies of oil make the Straits history and a redundant proposition, which will be sooner than later after this episode, one too many more from the Middle East. More likely by 2030-2035. China and Japan depend on it for 90% of imports, and India 50% with alternative supplies provided for India from the US and Russia. Germany is only dependent on the Straits for 6% of its imports showing how far Germany has come and how important renewables and alternative sources of oil such as Venezuela will become in the time ahead, in a two pronged strategy that does not forget the challenges posed by climate from fires and floods. Were not stuck with the Straits- Japan and China can and will find alternative sources and increase production of renewable energy in the way Germany has done to get to 6% of imports from that region. ...

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Gas at pump costs about $8 in Germany and France, $7 in UK and $4.50 in Canada- in the US $4 for March 2026. As far back as 2011-2014 gasoline prices averaged about $3.50 a gallon in the US. Today's $3.92 average in 2026 is only 12% higher than $3.50 of 10-15 years back in the US for gas prices at the pump. Gas pries before the war in Ukraine in 2017 were $5.67 a gallon ($1.50 a litre) with a price increase in 2026 10 years later to $8 an increase of 41%. By any comparison with European nations Americans are way better off in 2026 and also in comparison with 15 years back considering the 12% increase and the much higher wages today. The average annual wage salary was $43,000 back in 2010 compared to $65,000- $75,000 today. Much of this was achieved by increased shale production to make US oil self sufficient. Americans are clearly so much better off today with oil at an average price of $3.92 a gallon.  The higher price of oil also acts to increase incentives for accelerating renewable energy production which will make it possible to achieve a future free of fossil fuels while at the same time giving average wage Americans a chance for a better life during the transition. ...

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Modi in West Bengal - many rallies across the state for second phase of State Elections and goals for Vikshit Bharat (Modernized India 2047) with West Bengal as a key part in Paribortan or Transformation. The state has lagged far behind other states in India in industrial development, in women's rights, in standards of living, with much of the younger generation finding it hard to find jobs in a largely agricultural economy. State policies of the government have provided poor governance, lack of rule of law, and discouraged industries from setting up in the state, leading to a sense that the future is bleak for the state if this continues for any longer. As this poor state of governance has been happening for 15 years. Bengal played an important part in India's struggle for independence. Post war governments under the Congress party, Communist Party, and a local regional party TMC have all failed in succession to modernize the state economy and build its industries, leaving it as an agricultural backwater for the Indian economy. This election is an opportunity for the new generation of people in their 20's and 30's, for women, for all Bengalis to give modernization working together with the federal government and Modi a chance to set it on a new path to modernization.  ...

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A report by top FDA officials said that the agency's commissioner, who resigned in January, was improperly influenced by calls from Congressmen, in approving Meniflex. This is a product of RenGen Biologics Inc., a C- shaped pad device to repair injured knees. This after scientists at the agency had rejected it because it was not considered effective or safe.

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S&P downgraded France's credit rating from AAA to AA+ on Jan 13, 2012. S&P downgraded Italy's credit rating to BBB+ and Spain's credit rating to A. The AAA ratings for Germany, Netherlands and Finland were left unchanged. S&P stated its reasoning: "Today's ratings actions are primarily driven by our assessment that the policy initiatives that have been taken by European policy makers in recent weeks may be insufficient to fully address ongoing systemic stresses in the eurozone."

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This exceptional report from rural areas in France by Roger Cohen shows why the support is growing for the far right and the far left in rural areas and smaller towns outside the large cities which have suffered from high unemployment and neglected as technology and capital moved to other areas. Cohen talks to Nicholas Bay, secretary general of the National Front, who says this election is about patriotism, the nation state vs globalization, as the National Front tries to portray its opposition as being less pro-France, and less pro French culture. The centrist candidate Macron stands in front of a statue of Alexandre Dumas in Picardy, an hour northeast of Paris, and says he is for an "open patriotism" that embraces people of different origins and embraces refugees. Cohen attends a Le Pen rally in Metz, Lorraine, talks to a National Front mayor in Picardy and left party supporters in the town, talks to foreigners in the banlieu of Sevran. Cohen says a National Front victory is possible if enough voters who support the far left party of Melenchon do not vote for centrist candidate Macron, and enough voters of centre right Fillon supporting French culture and nationalism drift to Le Pen. As in the Dutch election with Moroccans derided by the far right the immigrant issue is a factor. Against this background is how events play out in the last weeks of the election. In March and April the events in the U.S. show a Trump administration moving to the centre, adopting a quieter and more constructive tone towards Mexico and immigrants. Relations with Russia have worsened after the U.S. response to the chemical attack in Syria, and the French public may now see this as a common threat to NATO and the European Union. As in the Dutch election a lot depends on the last weeks of the election and how well the centrist parties, the centre right and the centre left get their message across about what is to be gained by building anew on the foundations of the past without risking a lot on an uncertain path of referendums and exit from the European Union.   ...